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Terbium-Macrocycle Complexes as Chemical Sensors: Detection of an Aspirin Metabolite in Urine Using a Salicylurate-Specific Receptor Site

Esplin, Taran L. and Cable, Morgan L. and Gray, Harry B. and Ponce, Adrian (2010) Terbium-Macrocycle Complexes as Chemical Sensors: Detection of an Aspirin Metabolite in Urine Using a Salicylurate-Specific Receptor Site. Inorganic Chemistry, 49 (10). pp. 4643-4647. ISSN 0020-1669. https://resolver.caltech.edu/CaltechAUTHORS:20100610-083640997

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Abstract

Salicylurate (SU) is the major metabolite in urine of acetylsalicylic acid (aspirin) and can be used as a metric to monitor aspirin pharmacokinetics and as an indicator of appendicitis, anemia, and liver disease. Detection in urine and plasma currently requires solvent extraction or other sample handling prior to analysis. We present a simple method to quantify SU in urine via chelation to a terbium binary complex with the macrocycle 1,4,7,10-tetraazacyclododecane-1,7-bisacetate (DO2A). Binding of SU to form the [Tb(DO2A)(SU)]− ternary complex triggers intense luminescence under UV excitation due to an absorbance-energy transfer-emission mechanism. Here we report characterization of the [Tb(DO2A)(SU)]− ternary complex and application of this sensitized lanthanide luminescence method to quantify SU in urine samples following a low-dose aspirin regimen.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ic1003066 DOIUNSPECIFIED
http://pubs.acs.org/doi/abs/10.1021/ic1003066PublisherUNSPECIFIED
ORCID:
AuthorORCID
Cable, Morgan L.0000-0002-3680-302X
Gray, Harry B.0000-0002-7937-7876
Additional Information:© 2010 American Chemical Society. Received February 13, 2010. Publication Date (Web): April 21, 2010. The authors thank Mona Shahgholi for assistance withmass spectrometry. This research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautic and Space Administration and was sponsored by the NASA Astrobiology and Planetary Protection Programs (A.P.), the Department of Homeland Security Chemical and Biological Research & Development Program (A.P.), the NASA Graduate Student Research Program (M.L.C.), and the NASA Undergraduate Student Research Program (T.L.E.). Work at the Beckman Institute was supported by the NIH, NSF, and the Arnold and Mabel Beckman Foundation (H.B.G.).
Funders:
Funding AgencyGrant Number
JPL/CaltechUNSPECIFIED
NASA Astrobiology and Planetary Protection Programs (A.P.)UNSPECIFIED
Department of Homeland Security Chemical and Biological Research & Development ProgramUNSPECIFIED
NIHUNSPECIFIED
NSFUNSPECIFIED
Arnold and Mabel Beckman FoundationUNSPECIFIED
Issue or Number:10
Record Number:CaltechAUTHORS:20100610-083640997
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100610-083640997
Official Citation:Terbium-Macrocycle Complexes as Chemical Sensors: Detection of an Aspirin Metabolite in Urine Using a Salicylurate-Specific Receptor Site Taran L. Esplin, Morgan L. Cable, Harry B. Gray, Adrian Ponce Inorganic Chemistry 2010 49 (10), 4643-4647
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:18631
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Jun 2010 03:56
Last Modified:09 Mar 2020 13:18

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