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A robust coregistration method for in vivo studies using a first generation simultaneous PET/MR scanner

Ng, Thomas S. C. and Procissi, Daniel and Wu, Yibao and Jacobs, Russell E. (2010) A robust coregistration method for in vivo studies using a first generation simultaneous PET/MR scanner. Medical Physics, 37 (5). pp. 1995-2003. ISSN 0094-2405. PMCID PMC2866256. https://resolver.caltech.edu/CaltechAUTHORS:20100611-091816250

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Abstract

Purpose: Hybrid positron emission tomography (PET)/magnetic resonance (MR) imaging systems have recently been built that allow functional and anatomical information obtained from PET and MR to be acquired simultaneously. The authors have developed a robust coregistration scheme for a first generation small animal PET/MR imaging system and illustrated the potential of this system to study intratumoral heterogeneity in a mouse model. Methods: An alignment strategy to fuse simultaneously acquired PET and MR data, using the MR imaging gradient coordinate system as the reference basis, was developed. The fidelity of the alignment was evaluated over multiple study sessions. In order to explore its robustness in vivo, the alignment strategy was applied to explore the heterogeneity of glucose metabolism in a xenograft tumor model, using ^(18)F-FDG-PET to guide the acquisition of localized ^1H MR spectra within a single imaging session. Results: The alignment method consistently fused the PET/MR data sets with subvoxel accuracy (registration error mean=0.55 voxels, <0.28 mm); this was independent of location within the field of view. When the system was used to study intratumoral heterogeneity within xenograft tumors, a correlation of high ^(18)F-FDG-PET signal with high choline/creatine ratio was observed. Conclusions: The authors present an implementation of an efficient and robust coregistration scheme for multimodal noninvasive imaging using PET and MR. This setup allows time-sensitive, multimodal studies of physiology to be conducted in an efficient manner.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1118/1.3369447 DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866256/PubMed CentralArticle
ORCID:
AuthorORCID
Jacobs, Russell E.0000-0002-1382-8486
Additional Information:© 2010 American Association of Physicists in Medicine. Received 20 November 2009; revised 17 February 2010; accepted 3 March 2010; published 12 April 2010. The authors thank Dr. Andrew Raubitschek for providing the mice and tumors, Dr. Scott Fraser, Dr. Simon Cherry, Dr. Jinyi Qi, Dr. Ciprian Catana, and Dr. James Bading for advice on imaging issues and support, Hargun Sohi and Marucha Sanchez for animal handling, Sonia Collazo for computer assistance and Andrew Demyanenko for making the animal RF coil. The project was funded in part by NIBIB Grant No. R01 EB000993, NCRR Grant No. U24 RR021760, Mouse BIRN, a student fellowship from the SNM Education and Research Foundation, and the Beckman Institute.
Funders:
Funding AgencyGrant Number
National Institute of Biomedical Imaging and Bioengineering (NIBIB)R01 EB000993
National Center for Research Resources (NCRR)U24 RR021760
Mouse Biomedical Informatics Research Network (BIRN)UNSPECIFIED
SNM Education and Research FoundationUNSPECIFIED
Caltech Beckman InstituteUNSPECIFIED
Subject Keywords:biochemistry; biomedical MRI; positron emission tomography; robust control; sugar; tumours
Issue or Number:5
Classification Code:PACS: 87.19.lf; 87.57.uk; 87.15.R-; 87.61.-c.
PubMed Central ID:PMC2866256
Record Number:CaltechAUTHORS:20100611-091816250
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100611-091816250
Official Citation:A robust coregistration method for in vivo studies using a first generation simultaneous PET/MR scanner Thomas S. C. Ng, Daniel Procissi, Yibao Wu, and Russell E. Jacobs, Med. Phys. 37, 1995 (2010), DOI:10.1118/1.3369447
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:18650
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Jun 2010 04:28
Last Modified:03 Oct 2019 01:45

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