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Detestable or marvelous? Neuroanatomical correlates of character judgments

Croft, Katie E. and Duff, Melissa C. and Kovach, Christopher K. and Anderson, Steven W. and Adolphs, Ralph and Tranel, Daniel (2010) Detestable or marvelous? Neuroanatomical correlates of character judgments. Neuropsychologia, 48 (6). pp. 1789-1801. ISSN 0028-3932. PMCID PMC2862792.

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As we learn new information about the social and moral behaviors of other people, we form and update character judgments of them, and this can profoundly influence how we regard and act towards others. In the study reported here, we capitalized on two interesting neurological patient populations where this process of complex “moral updating” may go awry: patients with bilateral damage to ventromedial prefrontal cortex (vmPFC) and patients with bilateral damage to hippocampus (HC). We predicted that vmPFC patients, who have impaired emotion processing, would exhibit reduced moral updating, and we also investigated how moral updating might be affected by severe declarative memory impairment in HC patients. The vmPFC, HC, and brain-damaged comparison (BDC) participants made moral judgments about unfamiliar persons before and after exposure to social scenarios depicting the persons engaged in morally good, bad, or neutral behaviors. In line with our prediction, the vmPFC group showed the least amount of change in moral judgments, and interestingly, the HC group showed the most amount of change. These results suggest that the vmPFC and hippocampus play critical but complementary roles in updating moral character judgments about others: the vmPFC may attribute emotional salience to moral information, whereas the hippocampus may provide necessary contextual information from which to make appropriate character judgments.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Kovach, Christopher K.0000-0002-0117-151X
Adolphs, Ralph0000-0002-8053-9692
Additional Information:© 2010 Elsevier. Received 24 September 2009; revised 27 February 2010; accepted 1 March 2010. Available online 6 March 2010. We acknowledge Thomas Grabowski for reviewing the characterization of the lesions in the target and BDC groups, and the accuracy of the lesion overlap map depicted in Fig. 1, and Hanna Damasio for her expert tracing of the lesions of the patients. The authors would like to acknowledge Tony Buchanan, David Rudrauf, and Joel Bruss for their assistance with experimental design, data analysis, and lesion analysis, respectively. We thank Antonio Damasio for inspiring the title.
Funding AgencyGrant Number
National Alliance for Research on Schizophrenia and DepressionUNSPECIFIED
NIHP50 NS19632
NIHR01 DA022549
National Institute of Neurological Disorders and StrokeUNSPECIFIED
National Institute on Drug AbuseUNSPECIFIED
Subject Keywords:Ventromedial; Hippocampus; Moral; Social cognition; Memory
Issue or Number:6
PubMed Central ID:PMC2862792
Record Number:CaltechAUTHORS:20100625-093847294
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:18813
Deposited By: Tony Diaz
Deposited On:28 Jun 2010 00:03
Last Modified:09 Mar 2020 13:18

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