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An electrochemical intraocular drug delivery device

Li, Po-Ying and Shih, Jason and Lo, Ronalee and Saati, Saloomeh and Agrawal, Rajat and Humayun, Mark S. and Tai, Yu-Chong and Meng, Ellis (2008) An electrochemical intraocular drug delivery device. Sensors and Actuators A, 143 (1). pp. 41-48. ISSN 0924-4247. https://resolver.caltech.edu/CaltechAUTHORS:20100708-110900771

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Abstract

A microelectromechanical systems (MEMS) drug delivery device is investigated for the treatment of incurable ocular diseases. Unlike conventional ocular drug delivery devices, this MEMS device is capable of being refilled, features electronic control of the drug regimen, and enables targeted intraocular drug delivery. The refillable design permits long-term drug therapy and avoids repetitive surgeries. Electronic control of dosing is achieved by using electrolysis-actuated pumping to deliver pharmaceuticals directly to the intraocular space. A flexible Parylene transscleral cannula allows targeted delivery to tissues in both the anterior and posterior segments of the eye. This electrochemically driven drug delivery device was demonstrated to provide flow rates suitable for ocular drug therapy (pL/min to μL/min). Both continuous and bolus drug delivery modes were performed to achieve accurate delivery of a target volume of 250 nL. An encapsulation packaging technique was developed for acute surgical studies and preliminary ex vivo drug delivery experiments in porcine eyes were performed.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.sna.2007.06.034 DOIArticle
ORCID:
AuthorORCID
Humayun, Mark S.0000-0002-5830-5208
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2007 Elsevier B.V. Received 31 March 2007; revised 22 June 2007; accepted 26 June 2007. Available online 4 July 2007. This work was funded in part by Engineering Research Centers Program of the NSF under Award Number EEC-0310723 and Bausch & Lomb.We would like to thank Mr. Trevor Roper, Dr. Tuan Hoang, and members of the Biomedical Microsystems Lab at the University of Southern California.
Funders:
Funding AgencyGrant Number
NSFEEC-0310723
Bausch and LombUNSPECIFIED
Subject Keywords:drug delivery device; electrolysis pump; refillable reservoir; intraocular
Issue or Number:1
Record Number:CaltechAUTHORS:20100708-110900771
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100708-110900771
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:18950
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Jul 2010 17:45
Last Modified:09 Mar 2020 13:18

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