Lu, Bo and Xu, Tong and Zheng, Siyang and Goldkorn, Amir and Tai, Yu-Chong
(2010)
Parylene membrane slot filter for the capture, analysis and culture of viable circulating tumor cells.
In:
MEMS 2010: 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest.
Proceedings: IEEE Micro Electro Mechanical Systems.
IEEE
, pp. 935-938.
ISBN 978-1-4244-5764-9 .
http://resolver.caltech.edu/CaltechAUTHORS:20100713-150231303
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Abstract
This paper presents a method of capturing viable
circulating tumor cells (CTC) from human whole
blood using constant-pressure-driven filtration through
a specially designed parylene-C membrane “slot” filter.
More than 90% viable cancer cells could be recovered
from whole blood using the slot filter, with minimal
non-cancer blood cells left on the filter. The feasibility
of the telomerase activity measurement of a single
cancer cell taken from the filter after capture was
proven. The on-filter and off-filter cultures of the
captured cancer cells were also demonstrated.
| Item Type: | Book Section |
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| Additional Information: | © 2010 IEEE.
The funding of this project is provided by NIH/NCI
1R01CA141077-01, and The Hope Foundation
SWOG0421. |
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| Funders: | | Funding Agency | Grant Number |
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| NIH/National Cancer Institute (NCI) | 1R01CA141077-01 | | The Hope Foundation | SWOG0421 |
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| Other Numbering System: | | Other Numbering System Name | Other Numbering System ID |
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| INSPEC Accession Number | 11246665 |
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| Record Number: | CaltechAUTHORS:20100713-150231303 |
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| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:20100713-150231303 |
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| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. |
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| ID Code: | 19040 |
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| Collection: | CaltechAUTHORS |
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| Deposited By: |
Tony Diaz
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| Deposited On: | 13 Jul 2010 22:37 |
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| Last Modified: | 16 May 2017 22:55 |
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