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Parylene membrane slot filter for the capture, analysis and culture of viable circulating tumor cells

Lu, Bo and Xu, Tong and Zheng, Siyang and Goldkorn, Amir and Tai, Yu-Chong (2010) Parylene membrane slot filter for the capture, analysis and culture of viable circulating tumor cells. In: MEMS 2010: 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest. Proceedings: IEEE Micro Electro Mechanical Systems. IEEE , pp. 935-938. ISBN 978-1-4244-5764-9.

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This paper presents a method of capturing viable circulating tumor cells (CTC) from human whole blood using constant-pressure-driven filtration through a specially designed parylene-C membrane “slot” filter. More than 90% viable cancer cells could be recovered from whole blood using the slot filter, with minimal non-cancer blood cells left on the filter. The feasibility of the telomerase activity measurement of a single cancer cell taken from the filter after capture was proven. The on-filter and off-filter cultures of the captured cancer cells were also demonstrated.

Item Type:Book Section
Related URLs:
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2010 IEEE. The funding of this project is provided by NIH/NCI 1R01CA141077-01, and The Hope Foundation SWOG0421.
Funding AgencyGrant Number
NIH/National Cancer Institute (NCI)1R01CA141077-01
The Hope FoundationSWOG0421
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Other Numbering System NameOther Numbering System ID
INSPEC Accession Number11246665
Series Name:Proceedings: IEEE Micro Electro Mechanical Systems
Record Number:CaltechAUTHORS:20100713-150231303
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:19040
Deposited By: Tony Diaz
Deposited On:13 Jul 2010 22:37
Last Modified:03 Oct 2019 01:51

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