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Intercellular mechanotransduction during multicellular morphodynamics

Kim, Jin-Hong and Dooling, Lawrence J. and Asthagiri, Anand R. (2010) Intercellular mechanotransduction during multicellular morphodynamics. Journal of the Royal Society Interface, 7 . S341-S350. ISSN 1742-5689.

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Multicellular structures are held together by cell adhesions. Forces that act upon these adhesions play an integral role in dynamically re-shaping multicellular structures during development and disease. Here, we describe different modes by which mechanical forces are transduced in a multicellular context: (i) indirect mechanosensing through compliant substratum, (ii) cytoskeletal ‘tug-of-war’ between cell–matrix and cell–cell adhesions, (iii) cortical contractility contributing to line tension, (iv) stresses associated with cell proliferation, and (v) forces mediating collective migration. These modes of mechanotransduction are recurring motifs as they play a key role in shaping multicellular structures in a wide range of biological contexts. Tissue morphodynamics may ultimately be understood as different spatio-temporal combinations of a select few multicellular transformations, which in turn are driven by these mechanotransduction motifs that operate at the bicellular to multicellular length scale.

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Additional Information:© 2010 The Royal Society. Published online before print March 31, 2010. One contribution to a Theme Supplement ‘Mechanobiology’. We thank the Research Centre of Excellence in Mechanobiology at the National University of Singapore for hosting A.R.A. during the development of some of the ideas presented in this review; the members of the Asthagiri group for helpful discussions; and two anonymous reviewers for their suggestions. This work was supported by the NCI Physical Sciences of Oncology Center at USC (U54CA143907) and the National Institutes of Health grant R01-CA138899.
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NCI Physical Sciences of Oncology Center at USCU54CA143907
Subject Keywords:cell-cell adhesion; contractility; extracellular matrix; line tension; mechanotransduction; morphodynamics
Record Number:CaltechAUTHORS:20100809-152658931
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:19350
Deposited By: Tony Diaz
Deposited On:09 Aug 2010 23:48
Last Modified:03 Oct 2019 01:55

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