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The nucleotide sequence of a human immnnoglobulin C-gamma-1 gene

Ellison, Jay W. and Berson, Bennett J. and Hood, Leroy E. (1982) The nucleotide sequence of a human immnnoglobulin C-gamma-1 gene. Nucleic Acids Research, 10 (13). pp. 4071-4079. ISSN 0305-1048. http://resolver.caltech.edu/CaltechAUTHORS:ELLnar82

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Abstract

We report the nucleotide sequence of a gene encoding the constant region of a human immnnoglobulin γ1 heavy chain (Cγ1). A comparison of this sequence with those of the Cγ2 and Cγ4 genes reveals that these three human Cγ genes share considerable homology in both coding and noncoding regions. The nucleotide sequence differences indicate that these genes diverged from one another approximately 6–8 million years ago. An examination of hinge exons shows that these coding regions have evolved more rapidly than any other areas of the Cγ genes in terms of both base substitution and deletion–insertion events. Coding sequence diversity also is observed in areas of CH domains which border the hinge.


Item Type:Article
Additional Information:Copyright © 1982 Oxford University Press. Received 12 April 1982; Revised and Accepted 2 June 1982. This work was supported by a grant from the National Institutes of Health and a National Research Service Award from the National Institute of General Medical Sciences to J.E. We thank Karyl Minard for excellent technical assistance and Stephanie Canada for the preparation of the manuscript.
Issue or Number:13
Record Number:CaltechAUTHORS:ELLnar82
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:ELLnar82
Alternative URL:http://dx.doi.org/10.1093/nar/10.13.4071
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1940
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Feb 2006
Last Modified:26 Dec 2012 08:46

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