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Appetitive and Aversive Goal Values Are Encoded in the Medial Orbitofrontal Cortex at the Time of Decision Making

Plassmann, Hilke and O'Doherty, John P. and Rangel, Antonio (2010) Appetitive and Aversive Goal Values Are Encoded in the Medial Orbitofrontal Cortex at the Time of Decision Making. Journal of Neuroscience, 30 (32). pp. 10799-10808. ISSN 0270-6474. PMCID PMC6634706. https://resolver.caltech.edu/CaltechAUTHORS:20100831-101154929

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Abstract

An essential feature of choice is the assignment of goal values (GVs) to the different options under consideration at the time of decision making. This computation is done when choosing among appetitive and aversive items. Several groups have studied the location of GV computations for appetitive stimuli, but the problem of valuation in aversive contexts at the time of decision making has been ignored. Thus, although dissociations between appetitive and aversive components of value signals have been shown in other domains such as anticipatory and outcome values, it is not known whether appetitive and aversive GVs are computed in similar brain regions or in separate ones. We investigated this question using two different functional magnetic resonance imaging studies while human subjects placed real bids in an economic auction for the right to eat/avoid eating liked/disliked foods. We found that activity in a common area of the medial orbitofrontal cortex and the dorsolateral prefrontal cortex correlated with both appetitive and aversive GVs. These findings suggest that these regions might form part of a common network.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1523/JNEUROSCI.0788-10.2010 DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634706PubMed CentralArticle
ORCID:
AuthorORCID
Plassmann, Hilke0000-0001-9680-0763
O'Doherty, John P.0000-0003-0016-3531
Additional Information:© 2010 the authors. Received Feb. 12, 2010; revised June 15, 2010; accepted June 27, 2010. This work was supported by National Science Foundation Grant SES-0134618 and by a grant from the Gordon and Betty Moore Foundation to the Caltech Brain Imaging Center.
Funders:
Funding AgencyGrant Number
NSFSES-0134618
Gordon and Betty Moore FoundationUNSPECIFIED
Issue or Number:32
PubMed Central ID:PMC6634706
Record Number:CaltechAUTHORS:20100831-101154929
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100831-101154929
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:19737
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 Sep 2010 18:41
Last Modified:03 Oct 2019 02:01

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