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Functional roles for noise in genetic circuits

Eldar, Avigdor and Elowitz, Michael B. (2010) Functional roles for noise in genetic circuits. Nature, 467 (7312). pp. 167-173. ISSN 0028-0836. PMCID PMC4100692.

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The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or ‘noise’, in the levels of their components. Noise, far from just a nuisance, has begun to be appreciated for its essential role in key cellular activities. Noise functions in both microbial and eukaryotic cells, in multicellular development, and in evolution. It enables coordination of gene expression across large regulons, as well as probabilistic differentiation strategies that function across cell populations. At the longest timescales, noise may facilitate evolutionary transitions. Here we review examples and emerging principles that connect noise, the architecture of the gene circuits in which it is present, and the biological functions it enables. We further indicate some of the important challenges and opportunities going forward.

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Elowitz, Michael B.0000-0002-1221-0967
Additional Information:© 2010 Nature Publishing Group. We thank G. Su¨el, A. Raj, F. Tan and J. Rossant for providing images. We thank N. Wingreen, D. J. Anderson, R. Kishony, J.-G. Ojalvo, G. Su¨el, H. Y. Kueh and members of the Elowitz laboratory for discussions. Work in M.B.E.’s laboratory was supported by NIH grants R01GM079771, P50 GM068763, NSF CAREER Award 0644463 and the Packard Foundation. A.E. was supported by EMBO, the International Human Frontier Science Organization and a Baxter fellowship.
Funding AgencyGrant Number
NIHP50 GM068763
David and Lucile Packard FoundationUNSPECIFIED
European Molecular Biology Organization (EMBO)UNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Baxter fellowshipUNSPECIFIED
Subject Keywords:Molecular biology; Biophysics; Stem cells; Evolution
Issue or Number:7312
PubMed Central ID:PMC4100692
Record Number:CaltechAUTHORS:20100920-101630573
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:20036
Deposited By: Jason Perez
Deposited On:21 Sep 2010 18:23
Last Modified:20 Apr 2020 22:19

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