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Functional roles for noise in genetic circuits

Eldar, Avigdor and Elowitz, Michael B. (2010) Functional roles for noise in genetic circuits. Nature, 467 (7312). pp. 167-173. ISSN 0028-0836. PMCID PMC4100692. http://resolver.caltech.edu/CaltechAUTHORS:20100920-101630573

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Abstract

The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or ‘noise’, in the levels of their components. Noise, far from just a nuisance, has begun to be appreciated for its essential role in key cellular activities. Noise functions in both microbial and eukaryotic cells, in multicellular development, and in evolution. It enables coordination of gene expression across large regulons, as well as probabilistic differentiation strategies that function across cell populations. At the longest timescales, noise may facilitate evolutionary transitions. Here we review examples and emerging principles that connect noise, the architecture of the gene circuits in which it is present, and the biological functions it enables. We further indicate some of the important challenges and opportunities going forward.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/nature09326DOIArticle
http://www.nature.com/nature/journal/v467/n7312/full/nature09326.htmlPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100692PubMed CentralArticle
http://rdcu.be/uty0PublisherFree ReadCube access
ORCID:
AuthorORCID
Elowitz, Michael B.0000-0002-1221-0967
Additional Information:© 2010 Nature Publishing Group. We thank G. Su¨el, A. Raj, F. Tan and J. Rossant for providing images. We thank N. Wingreen, D. J. Anderson, R. Kishony, J.-G. Ojalvo, G. Su¨el, H. Y. Kueh and members of the Elowitz laboratory for discussions. Work in M.B.E.’s laboratory was supported by NIH grants R01GM079771, P50 GM068763, NSF CAREER Award 0644463 and the Packard Foundation. A.E. was supported by EMBO, the International Human Frontier Science Organization and a Baxter fellowship.
Funders:
Funding AgencyGrant Number
NIHR01GM079771
NIHP50 GM068763
NSFMCB-0644463
David and Lucile Packard FoundationUNSPECIFIED
European Molecular Biology Organization (EMBO)UNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Baxter fellowshipUNSPECIFIED
Subject Keywords:Molecular biology; Biophysics; Stem cells; Evolution
PubMed Central ID:PMC4100692
Record Number:CaltechAUTHORS:20100920-101630573
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20100920-101630573
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:20036
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:21 Sep 2010 18:23
Last Modified:25 Jul 2017 18:00

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