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Motor Preparatory Activity in Posterior Parietal Cortex is Modulated by Subjective Absolute Value

Iyer, Asha and Lindner, Axel and Kagan, Igor and Andersen, Richard A. (2010) Motor Preparatory Activity in Posterior Parietal Cortex is Modulated by Subjective Absolute Value. PLoS Biology, 8 (8). Art. No. e1000444. ISSN 1544-9173. PMCID PMC2914636. doi:10.1371/journal.pbio.1000444. https://resolver.caltech.edu/CaltechAUTHORS:20100920-101757081

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Abstract

For optimal response selection, the consequences associated with behavioral success or failure must be appraised. To determine how monetary consequences influence the neural representations of motor preparation, human brain activity was scanned with fMRI while subjects performed a complex spatial visuomotor task. At the beginning of each trial, reward context cues indicated the potential gain and loss imposed for correct or incorrect trial completion. FMRI-activity in canonical reward structures reflected the expected value related to the context. In contrast, motor preparatory activity in posterior parietal and premotor cortex peaked in high “absolute value” (high gain or loss) conditions: being highest for large gains in subjects who believed they performed well while being highest for large losses in those who believed they performed poorly. These results suggest that the neural activity preceding goal-directed actions incorporates the absolute value of that action, predicated upon subjective, rather than objective, estimates of one's performance.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1371/journal.pbio.1000444DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914636/PubMed CentralArticle
ORCID:
AuthorORCID
Lindner, Axel0000-0002-8201-788X
Kagan, Igor0000-0002-1814-4200
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2010 Iyer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funders:
Funding AgencyGrant Number
Gordon and Betty Moore FoundationUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
National Eye InstituteUNSPECIFIED
NIHUNSPECIFIED
Subject Keywords:antIPS, anterior aspect of the intraparietal sulcus; BOLD, blood oxygenation level dependent; fMRI, functional magnetic resonance imaging; GLM, general linear model; IPS, intraparietal sulcus; LIP, lateral intraparietal area; PMd, dorsal premotor cortex; postIPS, posterior aspect of the intraparietal sulcus; PPC, posterior parietal cortex; ROI, region of interest; SMA, supplementary motor area; SPL, superior parietal lobule
Issue or Number:8
PubMed Central ID:PMC2914636
DOI:10.1371/journal.pbio.1000444
Record Number:CaltechAUTHORS:20100920-101757081
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20100920-101757081
Official Citation:Iyer A, Lindner A, Kagan I, Andersen RA (2010) Motor Preparatory Activity in Posterior Parietal Cortex is Modulated by Subjective Absolute Value. PLoS Biol 8(8): e1000444. doi:10.1371/journal.pbio.1000444 Received: June 16, 2009; Accepted: June 24, 2010; Published: August 3, 2010. This work was supported by grants from the Moore Foundation, the Boswell Foundation, and the National Eye Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:20039
Collection:CaltechAUTHORS
Deposited By:INVALID USER
Deposited On:27 Sep 2010 16:35
Last Modified:08 Nov 2021 23:56

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