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End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans

Lee, Song-Gil and Brown, Joshua M. and Rogers, Claude J. and Matson, John B. and Krishnamurthy, Chithra and Rawat, Manish and Hsieh-Wilson, Linda C. (2010) End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans. Chemical Science, 1 (3). pp. 322-325. ISSN 2041-6520 . PMCID PMC3026345. http://resolver.caltech.edu/CaltechAUTHORS:20100920-112851817

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Abstract

Glycosaminoglycans are sulfated polysaccharides that play important roles in fundamental biological processes, such as cell division, viral invasion, cancer and neuroregeneration. The multivalent presentation of multiple glycosaminoglycan chains on proteoglycan scaffolds may profoundly influence their interactions with proteins and subsequent biological activity. However, the importance of this multivalent architecture remains largely unexplored, and few synthetic mimics exist for probing and manipulating glycosaminoglycan activity. Here, we describe a new class of end-functionalized ring-opening metathesis polymerization (ROMP) polymers that mimic the native-like, multivalent architecture found on chondroitin sulfate (CS) proteoglycans. We demonstrate that these glycopolymers can be readily integrated with microarray and surface plasmon resonance technology platforms, where they retain the ability to interact selectively with proteins. ROMP-based glycopolymers are part of a growing arsenal of chemical tools for probing the functions of glycosaminoglycans and for studying their interactions with proteins.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1039/c0sc00271b DOIArticle
http://pubs.rsc.org/en/Content/ArticleLanding/2010/SC/c0sc00271bPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026345/PubMed CentralArticle
ORCID:
AuthorORCID
Hsieh-Wilson, Linda C.0000-0001-5661-1714
Additional Information:© 2010 The Royal Society of Chemistry. Received 18th April 2010, Accepted 15th July 2010.
PubMed Central ID:PMC3026345
Record Number:CaltechAUTHORS:20100920-112851817
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20100920-112851817
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:20051
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Sep 2010 21:49
Last Modified:05 Apr 2019 18:42

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