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Dynamical fluctuations in biochemical reactions and cycles

Pressé, S. and Ghosh, K. and Phillips, R. and Dill, K. A. (2010) Dynamical fluctuations in biochemical reactions and cycles. Physical Review E, 82 (3). Art. No. 031905. ISSN 1539-3755. http://resolver.caltech.edu/CaltechAUTHORS:20101004-094321543

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Abstract

We develop theory for the dynamics and fluctuations in some cyclic and linear biochemical reactions. We use the approach of maximum caliber, which computes the ensemble of paths taken by the system, given a few experimental observables. This approach may be useful for interpreting single-molecule or few-particle experiments on molecular motors, enzyme reactions, ion-channels, and phosphorylation-driven biological clocks. We consider cycles where all biochemical states are observable. Our method shows how: (1) the noise in cycles increases with cycle size and decreases with the driving force that spins the cycle and (2) provides a recipe for estimating small-number features, such as probability of backward spin in small cycles, from experimental data. The back-spin probability diminishes exponentially with the deviation from equilibrium. We believe this method may also be useful for other few-particle nonequilibrium biochemical reaction systems.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1103/PhysRevE.82.031905 DOIUNSPECIFIED
http://pre.aps.org/abstract/PRE/v82/i3/e031905PublisherUNSPECIFIED
Additional Information:© 2010 The American Physical Society. Received 30 October 2009; revised 13 July 2010; published 15 September 2010. We appreciate the support from NIH Grant No. GM- 34993 to K.D. S.P. thanks the FQRNT for its financial support as well as J. van Drie and G. Peterson for their insights. K.G. acknowledges an FRF Grant from DU for financial support.
Funders:
Funding AgencyGrant Number
NIHGM-34993
Fonds Québécois de la Recherche sur la Nature et les Technologies (FQRNT) UNSPECIFIED
Denver UniversityUNSPECIFIED
Classification Code:PACS: 87.16.dj, 82.39.Rt, 87.10.Ca, 87.18.Tt
Record Number:CaltechAUTHORS:20101004-094321543
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20101004-094321543
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:20269
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Oct 2010 16:56
Last Modified:26 Dec 2012 12:29

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