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Hox Genes Regulate Muscle Founder Cell Pattern Autonomously and Regulate Morphogenesis Through Motor Neurons

Dutta, Devkanya and Umashankar, M. and Lewis, Edward. B. and Rodrigues, Veronica and VijayRaghavan, K. (2010) Hox Genes Regulate Muscle Founder Cell Pattern Autonomously and Regulate Morphogenesis Through Motor Neurons. Journal of Neurogenetics, 24 (3). pp. 95-108. ISSN 0167-7063. http://resolver.caltech.edu/CaltechAUTHORS:20101025-100209935

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Abstract

The differentiation of myoblasts to form functional muscle fibers is a consequence of interactions between the mesoderm and ectoderm. The authors examine the role of segment identity in directing these interactions by studying the role of Hox genes in patterning adult muscles in Drosophila. Using the `four-winged fly' to remove Ultrabithorax function in the developing adult, the authors alter the identity of the ectoderm of the third thoracic segment towards the second and show that this is sufficient to inductively alter most properties of the mesoderm—myoblast number, molecular diversity, and migration pattern—to that of the second thoracic segment. Not all aspects of myogenesis are determined by the segment identity of the ectoderm. The autonomous identity of the mesoderm is important for choosing muscle founder cells in the correct segmental pattern. The authors show this by removal of the function of Antennapedia, the Hox gene expressed in the mesoderm of the third thoracic segment. This results in the transformation of founder cells to a second-thoracic pattern. The authors also report a role for the nervous system in later aspects of muscle morphogenesis by specifically altering Ultrabithorax gene expression in motor neurons. Thus, ectoderm and mesoderm segment identities collaborate to direct muscle differentiation by affecting distinct aspects of the process.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.3109/01677063.2010.494317DOIUNSPECIFIED
http://informahealthcare.com/doi/abs/10.3109/01677063.2010.494317PublisherUNSPECIFIED
Additional Information:© 2010 Informa Healthcare USA, Inc. Received 3 February 2010; Accepted 16 May 2010. The authors would like to thank Sean Carroll, Danny Brower, Siegfried Roth, and Daniel Kiehart for antibodies. The support of the Central Imaging and Flow Facility of NCBS is gratefully acknowledged. This article has been written in honour of Erich Buchner, who has inspired many collaborators and colleagues hoping to follow his example and his joy of doing science. K.V.R. and V.R. would particularly like to express their gratitude to Erich for many fruitful interactions. V.R. was a postdoctoral fellow in Erich Buchner ’ s group at the Max-Planck Institut f ü r biologische Kybernetik, T übingen, Germany. Declaration of interest: This work was supported by the Department of Biotechnology (DBT), The Indo-French Centre for Advanced Scientifi c Research (CEFIPRA/ IFCPAR), and the National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research, to K.V.R. and a Kanwal Rekhi Fellowship to D.D.
Funders:
Funding AgencyGrant Number
Department of Biotechnology (DBT) UNSPECIFIED
Indo-French Centre for Advanced Scientific Research (CEFIPRA/IFCPAR) UNSPECIFIED
National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research UNSPECIFIED
Kanwal Rekhi Fellowship UNSPECIFIED
Subject Keywords:Antennapedia; dumbfounded; Hox; motor neurons; muscle; myogenesis; Ultrabithorax
Record Number:CaltechAUTHORS:20101025-100209935
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20101025-100209935
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:20498
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:30 Nov 2010 22:51
Last Modified:26 Dec 2012 12:33

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