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Effect of NRG1, GDNF, EGF and NGF in the Migration of a Schwann Cell Precursor Line

Cornejo, Martha and Nambi, Deborah and Walheim, Christopher and Somerville, Matthew and Walker, Jacquae and Kim, Lino and Ollison, Lauren and Diamante, Graciel and Vyawahare, Saurabh and de Bellard, Maria Elena (2010) Effect of NRG1, GDNF, EGF and NGF in the Migration of a Schwann Cell Precursor Line. Neurochemical Research, 35 (10). pp. 1643-1651. ISSN 0364-3190. PMCID PMC3299396.

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The Schwann cells are the myelinating glia of the peripheral nervous system that originated during development from the highly motile neural crest. However, we do not know what the guidance signals for the Schwann cell precursors are. Therefore, we set to test some of the known neurotrophins that are expressed early in developing embryos and have been shown to be critical for the survival and patterning of developing glia and neurons. The goal of this study was to determine more specifically if GDNF, NRG1 and NGF are chemoattractants and/or chemokinetic molecules for a Schwann cell precursor line, the Spl201. We performed live chemoattraction assays, with imaging and also presented these molecules as part of their growing substrate. Our results show for the first time that GDNF and NRG1 are potent chemoattractive and chemokinetic molecules for these cells while NGF is a chemokinetic molecule stimulating their motility.

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Additional Information:© 2010 Springer Science+Business Media, LLC. Accepted: 23 June 2010. Published online: 13 July 2010. We thank Sonsoles de Lacalle for help writing this manuscript. This work was partly supported by a NIH-MBRS SCORE-5S06GM048680-13 to MEdB.
Funding AgencyGrant Number
NIH-Minority Biomedical Research Support (MBRS)SCORE-5S06GM048680-13
Subject Keywords:Schwann cell precursors; NeuregulinB1; NGF; GDNF; Cell migration; Chemoattraction
Issue or Number:10
PubMed Central ID:PMC3299396
Record Number:CaltechAUTHORS:20101025-125742432
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Official Citation:Cornejo, M., D. Nambi, et al. (2010). "Effect of NRG1, GDNF, EGF and NGF in the Migration of a Schwann Cell Precursor Line." Neurochemical Research 35(10): 1643-1651.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:20510
Deposited By: Tony Diaz
Deposited On:30 Nov 2010 22:54
Last Modified:03 Oct 2019 02:11

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