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Extending the family table: Insights from beyond vertebrates into the regulation of embryonic development by FGFs

Tulin, Sarah and Stathopoulos, Angelike (2010) Extending the family table: Insights from beyond vertebrates into the regulation of embryonic development by FGFs. Birth Defects Research Part C – Embryo Today – Reviews, 90 (3). pp. 214-227. ISSN 1542-975X. PMCID PMC4121331. https://resolver.caltech.edu/CaltechAUTHORS:20101028-135126489

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Abstract

Since the discovery of fibroblast growth factors (FGFs) much focus has been placed on elucidating the roles for each vertebrate FGF ligand, receptor, and regulating molecules in the context of vertebrate development, human disorders and cancer. Studies in human, mouse, frog, chick, and zebrafish have made great contributions to our understanding of the role of FGFs in specific processes. However, in recent years, as more genomes are sequenced, information is becoming available from many non-vertebrate models and a more complete picture of the FGF superfamily as a whole is emerging. In some cases, less redundancy in these FGF signaling systems may allow for more mechanistic insights. Studies in sea anemones have highlighted how ancient FGF signaling is and helped provide insight into the evolution of the FGF gene family. Work in nematodes has shown that different splice forms can be used for functional specificity in invertebrate FGF signaling. Comparing FGFs between urochordates and vertebrates as well as between different insect species reveals important clues into the process of gene loss, duplication and subfunctionalization of FGFs throughout evolution. Finally, comparing all members of the FGF ligand superfamily reveals variability in many properties, which may point to a feature of FGFs as being highly adaptable with regards to protein structure and signaling mechanism. Further studies on FGF signaling outside of vertebrates is likely to continue to complement work in vertebrates by contributing additional insights to the FGF field and providing unexpected information that could be used for medical applications.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/bdrc.20182DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/bdrc.20182/abstractPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121331/PubMed CentralArticle
ORCID:
AuthorORCID
Stathopoulos, Angelike0000-0001-6597-2036
Additional Information:© 2010 Wiley-Liss, Inc. Article first published online: 16 Sep. 2010. The authors thank David Ornitz, David Matus and Stephen Green for helpful comments on the manuscript. The authors apologize to those whose work we were not able to include in this review due to space restrictions.
Subject Keywords:FGF signaling; evolution of signaling; invertebrate models
Issue or Number:3
PubMed Central ID:PMC4121331
Record Number:CaltechAUTHORS:20101028-135126489
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20101028-135126489
Official Citation:Tulin, S. and Stathopoulos, A. (2010), Extending the family table: Insights from beyond vertebrates into the regulation of embryonic development by FGFs. Birth Defects Research Part C: Embryo Today: Reviews, 90: 214–227. doi: 10.1002/bdrc.20182
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:20587
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:28 Oct 2010 22:47
Last Modified:03 Oct 2019 02:12

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