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Antibody therapy in Neurodegenerative Disease

Southwell, Amber L. and Patterson, Paul H. (2010) Antibody therapy in Neurodegenerative Disease. Reviews in the Neurosciences, 21 (4). pp. 273-287. ISSN 0334-1763.

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Advances in medical science have led to increased life expectancy and increased median age in the population. Because the symptoms of neurodegenerative diseases generally onset in mid- to late-life, a concomitant increase in the number of persons afflicted with these devastating diseases has occurred. Developing therapies for neurodegenerative diseases is of the highest priority due to the enormous cost of medical care required, as well as for the human suffering involved. Although caused by a variety of genetic and environmental insults, such diseases share commonalities. Many of these diseases are proteinopathies-diseases caused by misfolded, aggregating proteins. Antibodies that can recognize and remove misfolded proteins are ideally suited for proteinopathy therapeutics. The numerous intriguing advances in antibody-based therapies for neurodegenerative diseases are discussed in this review.

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Additional Information:© 2010 Freund & Pettman. Accepted: May 28, 2010. Molecular graphics images were produced using the UCSF Chimera package from the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco (supported by NIH P41 RR-O I 081).
Funding AgencyGrant Number
NIHP41 RR-01081
Subject Keywords:Alzheimer's disease; Parkinson's disease; Huntington's disease; immunotherapy; vaccination; immunization; intrabody
Issue or Number:4
Record Number:CaltechAUTHORS:20101110-134950528
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:20751
Deposited By: Tony Diaz
Deposited On:23 Nov 2010 22:45
Last Modified:03 Oct 2019 02:14

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