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Properties of small molecular drug loading and diffusion in a fluorinated PEG hydrogel studied by ^1H molecular diffusion NMR and ^(19)F spin diffusion NMR

Mathias, Errol V. and Aponte, Julia and Kornfield, Julia A. and Ba, Yong (2010) Properties of small molecular drug loading and diffusion in a fluorinated PEG hydrogel studied by ^1H molecular diffusion NMR and ^(19)F spin diffusion NMR. Colloid and Polymer Science, 288 (18). pp. 1655-1663. ISSN 0303-402X. https://resolver.caltech.edu/CaltechAUTHORS:20101215-145930575

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Abstract

R_f-PEG (fluoroalkyl double-ended poly(ethylene glycol)) hydrogel is potentially useful as a drug delivery depot due to its advanced properties of sol–gel two-phase coexistence and low surface erosion. In this study, ^1H molecular diffusion nuclear magnetic resonance (NMR) and ^(19)F spin diffusion NMR were used to probe the drug loading and diffusion properties of the R_f-PEG hydrogel for small anticancer drugs, 5-fluorouracil (FU) and its hydrophobic analog, 1,3-dimethyl-5-fluorouracil (DMFU). It was found that FU has a larger apparent diffusion coefficient than that of DMFU, and the diffusion of the latter was more hindered. The result of ^(19)F spin diffusion NMR for the corresponding freeze-dried samples indicates that a larger portion of DMFU resided in the R_f core/IPDU intermediate-layer region (where IPDU refers to isophorone diurethane, as a linker to interconnect the R_f group and the PEG chain) than that of FU while the opposite is true in the PEG–water phase. To understand the experimental data, a diffusion model was proposed to include: (1) hindered diffusion of the drug molecules in the R_f core/IPDU-intermediate-layer region; (2) relatively free diffusion of the drug molecules in the PEG-water phase (or region); and (3) diffusive exchange of the probe molecules between the above two regions. This study also shows that molecular diffusion NMR combined with spin diffusion NMR is useful in studying the drug loading and diffusion properties in hydrogels for the purpose of drug delivery applications.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s00396-010-2304-9 DOIUNSPECIFIED
http://www.springerlink.com/content/5w88120017162632/PublisherUNSPECIFIED
ORCID:
AuthorORCID
Kornfield, Julia A.0000-0001-6746-8634
Additional Information:© The Author(s) 2010. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. Received: 8 June 2010; Revised: 19 September 2010; Accepted: 20 September 2010; Published online: 5 October 2010. This research was supported by the NSF Grant 0351848 and NSF Grant 0619147 for an NMR facility upgrade at CSULA.
Funders:
Funding AgencyGrant Number
NSF0351848
NSF0619147
Subject Keywords:Fluoroalkyl double-ended poly(ethylene glycol); Hydrogel; 5-Fluorouracil; 1,3-Dimethyl-5-fluorouracil Dug delivery; Molecular diffusion; Spin diffusion; NMR
Issue or Number:18
Record Number:CaltechAUTHORS:20101215-145930575
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20101215-145930575
Usage Policy:This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
ID Code:21386
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Dec 2010 23:16
Last Modified:03 Oct 2019 02:23

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