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Emerging properties of animal gene regulatory networks

Davidson, Eric H. (2010) Emerging properties of animal gene regulatory networks. Nature, 468 (7326). pp. 911-920. ISSN 0028-0836. PMCID PMC3967874.

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Gene regulatory networks (GRNs) provide system level explanations of developmental and physiological functions in the terms of the genomic regulatory code. Depending on their developmental functions, GRNs differ in their degree of hierarchy, and also in the types of modular sub-circuit of which they are composed, although there is a commonly employed sub-circuit repertoire. Mathematical modelling of some types of GRN sub-circuit has deepened biological understanding of the functions they mediate. The structural organization of various kinds of GRN reflects their roles in the life process, and causally illuminates both developmental and evolutionary process.

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Additional Information:© 2010 Macmillan Publishers Limited. Published online 15 December 2010. I am grateful for the reviews of the manuscript by E. V. Rothenberg and I. S. Peter. This work was supported by NIH grants HD-37105 and GM-61005 and by the Lucille P. Markey Charitable Trust.
Funding AgencyGrant Number
Lucille P. Markey Charitable TrustUNSPECIFIED
Subject Keywords:Developmental biology; Molecular biology
Issue or Number:7326
PubMed Central ID:PMC3967874
Record Number:CaltechAUTHORS:20110103-131606819
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Official Citation:Davidson, E. H. (2010). "Emerging properties of animal gene regulatory networks." Nature 468(7326): 911-920.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:21547
Deposited By: Tony Diaz
Deposited On:04 Jan 2011 18:36
Last Modified:03 Oct 2019 02:25

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