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Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?

Lee, Yun Kyung and Mazmanian, Sarkis K. (2010) Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System? Science, 330 (6012). pp. 1768-1773. ISSN 0036-8075. PMCID PMC3159383. https://resolver.caltech.edu/CaltechAUTHORS:20110104-090936027

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Abstract

Although microbes have been classically viewed as pathogens, it is now well established that the majority of host-bacterial interactions are symbiotic. During development and into adulthood, gut bacteria shape the tissues, cells, and molecular profile of our gastrointestinal immune system. This partnership, forged over many millennia of coevolution, is based on a molecular exchange involving bacterial signals that are recognized by host receptors to mediate beneficial outcomes for both microbes and humans. We explore how specific aspects of the adaptive immune system are influenced by intestinal commensal bacteria. Understanding the molecular mechanisms that mediate symbiosis between commensal bacteria and humans may redefine how we view the evolution of adaptive immunity and consequently how we approach the treatment of numerous immunologic disorders.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1126/science.1195568 DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159383PubMed CentralArticle
ORCID:
AuthorORCID
Mazmanian, Sarkis K.0000-0003-2713-1513
Additional Information:© 2011 American Association for the Advancement of Science. We thank members of the Mazmanian laboratory for their critical review of the manuscript. Supported by NIH grants DK078938, DK083633, and AI088626; the Damon Runyon Cancer Research Foundation; and the Crohn’s and Colitis Foundation of America (S.K.M.).
Funders:
Funding AgencyGrant Number
NIHDK078938
NIHDK083633
NIHAI088626
Damon Runyon Cancer Research FoundationUNSPECIFIED
Crohn's and Colitis Foundation of AmericaUNSPECIFIED
Issue or Number:6012
PubMed Central ID:PMC3159383
Record Number:CaltechAUTHORS:20110104-090936027
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110104-090936027
Official Citation:Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System? / Yun Kyung Lee and Sarkis K. Mazmanian. Science 24 December 2010: 330 (6012), 1768-1773. [DOI:10.1126/science.1195568]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:21566
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Jan 2011 19:35
Last Modified:14 Apr 2020 22:36

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