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THz in biology and medicine: toward quantifying and understanding the interaction of millimeter- and submillimeter-waves with cells and cell processes

Siegel, Peter H. and Pikov, Victor (2010) THz in biology and medicine: toward quantifying and understanding the interaction of millimeter- and submillimeter-waves with cells and cell processes. In: Optical interactions with tissues and cells XXI. Proceedings of SPIE. No.7562. Society of Photo-optical Instrumentation Engineers , Bellingham, WA. ISBN 978-0-8194-7958-7. https://resolver.caltech.edu/CaltechAUTHORS:20110105-085607229

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Abstract

As the application and commercial use of millimeter- and submillimeter-wavelength radiation become more widespread, there is a growing need to understand and quantify both the coupling mechanisms and the impact of this long wavelength energy on biological function. Independent of the health impact of high doses of radio frequency (RF) energy on full organisms, which has been extensively investigated, there exists the potential for more subtle effects, which can best be quantified in studies which examine real-time changes in cellular functions as RF energy is applied. In this paper we present the first real time examination of RF induced changes in cellular activity at absorbed power levels well below the existing safe exposure limits. Fluorescence microscopy imaging of immortalized epithelial and neuronal cells in vitro indicate increased cellular membrane permeability and nanoporation after short term exposure to modest levels (10-50 mW/cm2) of RF power at 60 GHz. Sensitive patch clamp measurements on pyramidal neurons in cortical slices of neonatal rats showed a dramatic increase in cellular membrane permeability resulting either in suppression or facilitation of neuronal activity during exposure to sub-μW/cm2 of RF power at 60 GHz. Non-invasive modulation of neuronal activity could prove useful in a variety of health applications from suppression of peripheral neuropathic pain to treatment of central neurological disorders.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.845380DOIArticle
http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1343993PublisherArticle
ORCID:
AuthorORCID
Siegel, Peter H.0000-0002-2539-4646
Additional Information:© 2010 SPIE. The authors are indebted to Caltech Professors Scott E. Fraser of the Biological Imaging Center, and David B. Rutledge of the department of Electrical Engineering for facilities support, programmatic and technical advice and continuous encouragement. Patch clamp measurements would not have been possible without the enthusiastic involvement, perseverance and tremendous skills of Huntington Medical Research Institute’s Dr. Michael Harrington and Xianghong Arakaki. This work was supported under limited carryover funds from NIH grant 1 K25 EB00109, two months of discretionary salary support from the NASA Jet Propulsion Laboratory office of the chief scientist, and a significant amount of personal time on the part of both authors.
Funders:
Funding AgencyGrant Number
NIH1 K25 EB00109
NASA/JPLUNSPECIFIED
Subject Keywords:Millimeter Waves; Cells; Neuronal Activity; Non-Invasive
Series Name:Proceedings of SPIE
Issue or Number:7562
Record Number:CaltechAUTHORS:20110105-085607229
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110105-085607229
Official Citation:Peter H. Siegel and Victor Pikov "THz in biology and medicine: toward quantifying and understanding the interaction of millimeter- and submillimeter-waves with cells and cell processes", Proc. SPIE 7562, Optical Interactions with Tissues and Cells XXI, 75620H (February 22, 2010); doi:10.1117/12.845380; http://dx.doi.org/10.1117/12.845380
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:21594
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Jan 2011 17:51
Last Modified:09 Mar 2020 13:19

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