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An Algorithm for Autonomous Isolation of Neurons in Extracellular Recordings

Branchaud, Edward A. and Burdick, Joel W. and Andersen, Richard A. (2006) An Algorithm for Autonomous Isolation of Neurons in Extracellular Recordings. In: Proceedings of the First IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics : BioRob 2006. IEEE , Piscataway, NJ, pp. 939-945. ISBN 978-1-4244-0039-3.

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This paper describes novel multi-electrode systems that can autonomously position recording electrodes inside cortical tissue so as to isolate and then maintain optimal extracellular signal recording quality without human intervention. Autonomous microdrives can be used to improve the quality and efficiency of acute recordings that are needed for basic research in neurophysiology. They also offer the potential to increase the longevity and quality of chronic recordings and will serve as the front end of neuroprosthetic systems that aid the handicapped. We first describe the autonomous positioning algorithm, and its implementation as a finite state machine. We have deployed the algorithm on both conventional acute recording micro-drives and a novel miniature robot microdrive. Experimental results in monkey cortex are presented.

Item Type:Book Section
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Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2006 IEEE. Issue Date: 20-22 Feb. 2006; Date of Current Version: 05 July 2006. This work has been supported by NIH and DARPA. We thank Jorge Cham, Michael Wolf, and the members of the Andersen lab at Caltech, especially Bradley Greger, Bijan Pesaran, Kelsie Pesja and Nicole Sammons.
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Subject Keywords:Brain-Machine Interface; Neural Recording; Control Algorithm
Record Number:CaltechAUTHORS:20110121-100428555
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Official Citation:Branchaud, E.A.; Burdick, J.W.; Andersen, R.A.; , "An Algorithm for Autonomous Isolation of Neurons in Extracellular Recordings," Biomedical Robotics and Biomechatronics, 2006. BioRob 2006. The First IEEE/RAS-EMBS International Conference on , vol., no., pp.939-945, 20-22 Feb. 2006 doi: 10.1109/BIOROB.2006.1639212 URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:21846
Deposited On:24 Jan 2011 17:45
Last Modified:09 Nov 2021 16:00

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