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Conserved and Variable Regions in the Subunits of Brain Type II Ca^(2+)/Calmodulin-Dependent Protein Kinase

Bulleit, Robert F. and Bennett, Mark K. and Molloy, Sean S. and Hurley, James B. and Kennedy, Mary B. (2008) Conserved and Variable Regions in the Subunits of Brain Type II Ca^(2+)/Calmodulin-Dependent Protein Kinase. Neuron, 60 (3). pp. 401-402. ISSN 0896-6273. doi:10.1016/j.neuron.2008.10.024.

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Brain type II Ca^(2+)/calmodulin-dependent protein kinase is a holoenzymecomposed of several copies each of three subunits, α (50 kd), β (60 kd), and β’ (58 kd), in varying proportions. The deduced amino acid sequences of α (reported here) and β are highly similar but not identical. The major difference between them is the deletion from α of two short segments (residues 316–339 and 354–392 in β). cDNAs that appear to encode β’ are identical to b except for the deletion of a segment encoding residues 378–392. Thus, the structural differences among α, β, and β’ arise primarily from deletions (or insertions) in a variable region lying immediately carboxyl to the protein kinase and calmodulin-binding domains. The α and β subunits are encoded by distinct genes expressed primarily, if not exclusively, in brain. Rather than being encoded by a third gene, β’ may arise by alternative splicing of the β gene transcript.

Item Type:Article
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Kennedy, Mary B.0000-0003-1369-0525
Additional Information:© 2008 Elsevier Inc. Available online 5 November 2008.
Issue or Number:3
Record Number:CaltechAUTHORS:20110127-153401744
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Official Citation:Mary B. Kennedy, Reflections, Neuron, Volume 60, Issue 3, 6 November 2008, Pages 401-402, ISSN 0896-6273, DOI: 10.1016/j.neuron.2008.10.024. (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:21913
Deposited By: Tony Diaz
Deposited On:04 Feb 2011 21:28
Last Modified:09 Nov 2021 16:01

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