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Collective Cell Migration on Artificial Extracellular Matrix Proteins Containing Full-Length Fibronectin Domains

Fong, Eileen and Tirrell, David A. (2010) Collective Cell Migration on Artificial Extracellular Matrix Proteins Containing Full-Length Fibronectin Domains. Advanced Materials, 22 (46). 5271-5275 . ISSN 0935-9648. PMCID PMC3027490. http://resolver.caltech.edu/CaltechAUTHORS:20110202-085127824

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Abstract

Protein-based biomaterials that promote rapid wound healing are prepared by expression of artificial genes in bacterial cells. Artificial extracellular matrix proteins containing full-length fibronectin domains 9 and 10 exhibit strong α_5β_1 integrin binding and support rapid spreading, proliferation, and collective migration of fibroblasts.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/adma.201002448 DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027490PubMed CentralArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: July 7, 2010; Revised: August 11, 2010; Published online: September 30, 2010. The authors thank Drs. Stacey Maskarinec and Shelly Tzlil for discussions. We acknowledge Dr. Anand Asthagiri for Rat-1 fibroblasts and generous access to the fluorescence microscope. E. F. is supported in part by the Nanyang Overseas Scholarship, Singapore. This work is supported by NIH EB001971, by the NSF Center for Science and Engineering of Materials, and by the Armed Forces Institute for Regenerative Medicine Wake Forest–Pittsburgh Consortium.
Funders:
Funding AgencyGrant Number
Nanyang Overseas ScholarshipUNSPECIFIED
NIHEB001971
NSFUNSPECIFIED
Armed Forces Institute for Regenerative Medicine Wake Forest-Pittsburgh Consortium UNSPECIFIED
Subject Keywords:wound healing; extracellular matrices; artificial proteins; hybrid materials
PubMed Central ID:PMC3027490
Record Number:CaltechAUTHORS:20110202-085127824
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20110202-085127824
Official Citation:Fong, E. and Tirrell, D. A. (2010), Collective Cell Migration on Artificial Extracellular Matrix Proteins Containing Full-Length Fibronectin Domains. Advanced Materials, 22: 5271–5275. doi: 10.1002/adma.201002448
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:21961
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 Feb 2011 21:41
Last Modified:09 May 2019 20:49

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