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Planar Cell Polarity Acts Through Septins to Control Collective Cell Movement and Ciliogenesis

Kim, Su Kyoung and Shindo, Asako and Park, Tae Joo and Oh, Edwin C. and Ghosh, Srimoyee and Gray, Ryan S. and Lewis, Richard A. and Johnson, Colin A. and Attie-Bittach, Tania and Katsanis, Nicholas and Wallingford, John B. (2010) Planar Cell Polarity Acts Through Septins to Control Collective Cell Movement and Ciliogenesis. Science, 329 (5997). pp. 1337-1340. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20110208-084815058

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Abstract

The planar cell polarity (PCP) signaling pathway governs collective cell movements during vertebrate embryogenesis, and certain PCP proteins are also implicated in the assembly of cilia. The septins are cytoskeletal proteins controlling behaviors such as cell division and migration. Here, we identified control of septin localization by the PCP protein Fritz as a crucial control point for both collective cell movement and ciliogenesis in Xenopus embryos. We also linked mutations in human Fritz to Bardet-Biedl and Meckel-Gruber syndromes, a notable link given that other genes mutated in these syndromes also influence collective cell movement and ciliogenesis. These findings shed light on the mechanisms by which fundamental cellular machinery, such as the cytoskeleton, is regulated during embryonic development and human disease.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1191184 DOIArticle
http://www.sciencemag.org/content/329/5997/1337.abstractPublisherArticle
ORCID:
AuthorORCID
Ghosh, Srimoyee0000-0002-7820-6741
Additional Information:© 2010 American Association for the Advancement of Science. Received for publication 20 April 2010. Accepted for publication 19 July 2010. We thank P. Abitua for technical assistance; E. Spiliotis for the antibodies; and A. Ewald, B. Mitchell, E. Brooks, and K. Smith for critical discussions and reading. This work was supported by grants from the Uehara Memorial Foundation (A.S.); National Institute of General Medical Science (NIH), March of Dimes, Burroughs Wellcome Fund, the Sandler Program for Asthma Research, and the Texas Advanced Research Program (J.B.W.); National Institute of Child Health and Human Development and National Institute of Digestive Diseases and Kidney Disease (NIH) (N.K.). N.K. is the George W. Brumley Professor. J.B.W. is an Early Career Scientist of the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
Uehara Memorial FoundationUNSPECIFIED
National Institute of General Medical SciencesUNSPECIFIED
March of DimesUNSPECIFIED
Burroughs Wellcome FundUNSPECIFIED
Sandler Program for Asthma ResearchUNSPECIFIED
Texas Advanced Research ProgramUNSPECIFIED
National Institute of Child Health and Human Development (NICHD)UNSPECIFIED
National Institute of Digestive Diseases and Kidney DiseaseUNSPECIFIED
NIHUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:5997
Record Number:CaltechAUTHORS:20110208-084815058
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110208-084815058
Official Citation:Kim, S. K., A. Shindo, et al. (2010). "Planar Cell Polarity Acts Through Septins to Control Collective Cell Movement and Ciliogenesis." Science 329(5997): 1337-1340.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:22065
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 Feb 2011 19:49
Last Modified:03 Oct 2019 02:33

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