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Assist-as-needed training paradigms for robotic rehabilitation of spinal cord injuries

Cai, Lance L. and Fong, Andy J. and Liang, Yongqiang and Burdick, Joel and Edgerton, V. Reggie (2006) Assist-as-needed training paradigms for robotic rehabilitation of spinal cord injuries. In: Proceedings 2006 IEEE International Conference on Robotics and Automation. IEEE , Piscataway, NJ, pp. 3504-3511. ISBN 0-7803-9505-0.

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This paper introduces a new “assist-as-needed” (AAN) training paradigm for rehabilitation of spinal cord injuries via robotic training devices. In the pilot study reported in this paper, nine female adult Swiss-Webster mice were divided into three groups, each experiencing a different robotic training control strategy: a fixed training trajectory (Fixed Group, A), an AAN training method without interlimb coordination (Band Group, B), and an AAN training method with bilateral hindlimb coordination (Window Group, C). Fourteen days after complete transection at the mid-thoracic level, the mice were robotically trained to step in the presence of an acutely administered serotonin agonist, quipazine, for a period of six weeks. The mice that received AAN training (Groups B and C) show higher levels of recovery than Group A mice, as measured by the number, consistency, and periodicity of steps realized during testing sessions. Group C displays a higher incidence of alternating stepping than Group B. These results indicate that this training approach may be more effective than fixed trajectory paradigms in promoting robust post-injury stepping behavior. Furthermore, the constraint of interlimb coordination appears to be an important contribution to successful training.

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Additional Information:© 2006 IEEE. Issue Date: 15-19 May 2006. Date of Current Version: 26 June 2006. This work is supported by the Christopher Reeve Paralysis Foundation, the National Institutes of Child Health and Humane Development and the National Institute of Neural Disorders and Stroke.
Funding AgencyGrant Number
Christopher Reeve Paralysis FoundationUNSPECIFIED
National Institute of Child Health and Human Development (NICHD)UNSPECIFIED
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
Subject Keywords:assist-as-needed; rehabilitative robotics; spinal cord injury
Record Number:CaltechAUTHORS:20110209-103455742
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Official Citation:Cai, L.L.; Fong, A.J.; Yongqiang Liang; Burdick, J.; Edgerton, V.R.; , "Assist-as-needed training paradigms for robotic rehabilitation of spinal cord injuries," Robotics and Automation, 2006. ICRA 2006. Proceedings 2006 IEEE International Conference on , vol., no., pp.3504-3511, 15-19 May 2006 doi: 10.1109/ROBOT.2006.1642237 URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:22092
Deposited By: Tony Diaz
Deposited On:10 Mar 2011 00:46
Last Modified:09 Nov 2021 16:02

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