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Magnetic nanoparticle transport within flowing blood and into surrounding tissue

Nacev​, A. and Beni​, C. and Bruno, O. and Shapiro, B. (2010) Magnetic nanoparticle transport within flowing blood and into surrounding tissue. Nanomedicine, 5 (9). pp. 1459-1466. ISSN 1743-5889. PMCID PMC3057021.

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Magnetic drug delivery refers to the physical confinement of therapeutic magnetic nanoparticles to regions of disease, tumors, infections and blood clots. Predicting the effectiveness of magnetic focusing in vivo is critical for the design and use of magnetic drug delivery systems. However, current simple back-of-the-envelope estimates have proven insufficient for this task. In this article, we present an analysis of nanoparticle distribution, in and around a single blood vessel (a Krogh tissue cylinder), located at any depth in the body, with any physiologically relevant blood flow velocity, diffusion and extravasation properties, and with any applied magnetic force on the particles. For any such blood vessel our analysis predicts one of three distinct types of particle behavior (velocity dominated, magnetic dominated or boundary-layer formation), which can be uniquely determined by looking up the values of three nondimensional numbers we define. We compare our predictions to previously published magnetic-focusing in vitro and in vivo studies. Not only do we find agreement between our predictions and prior observations, but we are also able to quantitatively explain behavior that was not understood previously.

Item Type:Article
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URLURL TypeDescription DOIArticle CentralArticle
Bruno, O.0000-0001-8369-3014
Additional Information:© 2010 Future Medicine Ltd. This research was supported in part by NIBIB/NIH grant number R21EB009265. We would like to thank the support provided by a NPSC graduate fellowship in addition to support from the Air Force Office of Scientific Research and the National Science Foundation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Funding AgencyGrant Number
National Physical Science ConsortiumUNSPECIFIED
Air Force Office of Scientific Research (AFOSR)UNSPECIFIED
Subject Keywords:blood vessels; ferromagnetic nanoparticles; in vivo experiments; magnetic drug targeting; nondimensional parameters; simulations; tissue treatment depth
Issue or Number:9
PubMed Central ID:PMC3057021
Record Number:CaltechAUTHORS:20110214-092710313
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Official Citation:Magnetic nanoparticle transport within flowing blood and into surrounding tissue A Nacev, C Beni, O Bruno and B Shapiro Nanomedicine 2010 5:9, 1459-1466
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:22159
Deposited By: Tony Diaz
Deposited On:10 Mar 2011 00:19
Last Modified:03 Oct 2019 02:35

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