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Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides

Coull, Jason J. and He, Guocheng and Melander, Christian and Rucker, Victor C. and Dervan, Peter B. and Margolis, David M. (2002) Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides. Journal of Virology, 76 (23). pp. 12349-12354. ISSN 0022-538X. PMCID PMC136904. https://resolver.caltech.edu/CaltechAUTHORS:COUjvir02

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Abstract

The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in vitro and within cells via direct access to chromatin, resulting in increased LTR expression.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136904/PubMed CentralArticle
https://doi.org/10.1128/JVI.76.23.12349-12354.2002DOIUNSPECIFIED
https://doi.org/10.1128/JVI.76.23.12349-12354.2002DOIUNSPECIFIED
ORCID:
AuthorORCID
Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 2002 American Society for Microbiology. Received 4 June 2002/ Accepted 28 August 2002 We thank H. Johnson for excellent technical assistance. We thank R. Koup and R. Gaynor for advice and J. V. Garcia, D. Sodora, and U. Hansen for advice and careful review. The following reagents were obtained through the AIDS Research and Reference Reagent Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH): HeLaCD4-CAT from Barbara K. Felber and George N. Pavlakis and ACH-2 from Thomas Folks. This work was supported by an NIH postdoctoral grant (GM19789-02) to C.M., an NIH grant (AI 45297) to D.M.M., and an NIH grant (GM51747) to P.B.D.
Funders:
Funding AgencyGrant Number
NIH Postdoctoral FellowshipGM19789-02
NIHAI-45297
NIHGM-51747
Issue or Number:23
PubMed Central ID:PMC136904
Record Number:CaltechAUTHORS:COUjvir02
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:COUjvir02
Official Citation:Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides Jason J. Coull, Guocheng He, Christian Melander, Victor C. Rucker, Peter B. Dervan, and David M. Margolis J. Virol. December 2002 76:23 12349-12354; doi:10.1128/JVI.76.23.12349-12354.2002
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:2231
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:17 Mar 2006
Last Modified:26 Nov 2019 11:15

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