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Memories for emotional autobiographical events following unilateral damage to medial temporal lobe

Buchanan, Tony W. and Tranel, Daniel and Adolphs, Ralph (2006) Memories for emotional autobiographical events following unilateral damage to medial temporal lobe. Brain, 129 (1). pp. 115-127. ISSN 0006-8950. doi:10.1093/brain/awh672.

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Abnormalities of both memory and emotion have been reported in patients with unilateral damage to the anteromedial temporal lobe, probably reflecting the functions of the amygdala and hippocampus in these processes. Emotion and memory are also known to interact: emotional experiences often leave remarkably durable autobiographical memories. To explore this interaction, and to extend prior studies to the domain of autobiographical memory, we investigated the recollection of real-life emotional events in patients with unilateral damage to the anteromedial temporal lobe. Twenty-three patients who had undergone unilateral temporal lobectomy for the treatment of epilepsy (12 left, 11 right) and 20 healthy comparison participants completed an emotional autobiographical memory test. Participants were asked to recollect their five most emotional memories from any time in their lives and then they completed a word-cued autobiographical memory task. Participants dated each memory and gave ratings on scales of pleasantness, intensity, significance, novelty, vividness and frequency of rehearsal. Left temporal lobectomy (LTL) and healthy comparison groups generated similar numbers of pleasant and unpleasant memories, whereas the right temporal lobectomy (RTL) group produced significantly fewer memories of unpleasant events (P < 0.01). When memories were further categorized according to pleasantness and intensity, the RTL group produced significantly fewer unpleasant/high intensity memories than the other groups (P < 0.01). All groups reported more memories from between the ages of 10 and 30 (the so-called autobiographical memory ‘bump’). The results demonstrate a positive bias in the recollection of autobiographical memory following right-sided anteromedial temporal damage. This finding is consistent with the notion that the right, but not the left, anteromedial temporal lobe is involved in the retrieval of negatively valenced, high-intensity memories.

Item Type:Article
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URLURL TypeDescription
Adolphs, Ralph0000-0002-8053-9692
Additional Information:© The Author (2005). Published by Oxford University Press on behalf of the Guarantors of Brain. Received March 25, 2005. Revised August 2, 2005. Accepted October 6, 2005. Advance Access publication November 16, 2005. The authors would like to thank Benjamin R. Lewis and Kodi Scheer for assistance in data collection. This work was supported by an NRSA from NIA to T.W.B., NINDS Program Project Grant P01 NS19632 and NIMH R01 067681.
Funding AgencyGrant Number
NIHP01 NS19632
NIHR01 067681
NIH Predoctoral FellowshipUNSPECIFIED
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
Subject Keywords:hippocampus; amygdala; autobiographical memory; emotion; temporal lobectomy
Issue or Number:1
Record Number:CaltechAUTHORS:20110218-091829945
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:22372
Deposited By: Ruth Sustaita
Deposited On:18 Feb 2011 17:41
Last Modified:09 Nov 2021 16:04

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