Rodger, Damien C. and Li, Wen and Ameri, Hossein and Ray, Aditi and Weiland, James D. and Humayun, Mark S. and Tai, Yu-Chong (2006) Flexible Parylene-based Microelectrode Technology for Intraocular Retinal Prostheses. In: 2006 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems. IEEE , Piscataway, N.J., pp. 743-746. ISBN 1-4244-0139-9. https://resolver.caltech.edu/CaltechAUTHORS:20110218-111423210
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Abstract
We present the first single metal layer flexible microelectrode arrays designed for intraocular implantation that utilize parylene C as their primary structural and insulating material. These electrodes are fabricated as a key component of an intraocular retinal prosthesis comprising a radio-frequency coil for power and data transfer, a packaged high lead-count telemetry-recovery and driving application-specific integrated circuit (ASIC), and a high-density epiretinal stimulating microelectrode array for the treatment of retinal degenerative blindness in humans. Electrochemical tests have demonstrated that these thin-film platinum electrodes perform as necessary for neuronal stimulation. A novel bioconformal MEMS geometry for a complete intraocular system with capsular retaining-wings that enables all the components of the system to be implanted and retained within the lens capsule and vitreous cavity of the eye is also presented. The efficacy of this geometry when compared with a previous model without capsular retaining-wings has been verified by surgical implantation in animal models.
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| Additional Information: | © 2006 IEEE. Issue Date: 18-21 Jan. 2006, Date of Current Version: 19 March 2007. This work was supported in part by the Engineering Research Centers Program of the National Science Foundation under NSF Award Number EEC-0310723, and by a fellowship from the Whitaker Foundation (D.R.). The authors especially wish to thank Mr. Trevor Roper and other members of the Caltech Micromachining Laboratory for their valuable assistance. | |||||||||
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| Subject Keywords: | bioMEMS; electrode array; neural prosthesis; parylene; retinal prosthesis | |||||||||
| DOI: | 10.1109/NEMS.2006.334886 | |||||||||
| Record Number: | CaltechAUTHORS:20110218-111423210 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20110218-111423210 | |||||||||
| Official Citation: | Rodger, D.C.; Wen Li; Ameri, H.; Ray, A.; Weiland, J.D.; Humayun, M.S.; Yu-Chong Tai; , "Flexible Parylene-based Microelectrode Technology for Intraocular Retinal Prostheses," Nano/Micro Engineered and Molecular Systems, 2006. NEMS '06. 1st IEEE International Conference on , vol., no., pp.743-746, 18-21 Jan. 2006 doi: 10.1109/NEMS.2006.334886 URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4135059&isnumber=4084516 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 22383 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Benjamin Perez | |||||||||
| Deposited On: | 18 Feb 2011 21:03 | |||||||||
| Last Modified: | 09 Nov 2021 16:04 |
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