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Flow optimization study of a batch microfluidics PET tracer synthesizing device

Elizarov, Arkadij M. and Meinhart, Carl and Miraghaie, Reza and van Dam, R. Michael and Huang, Jiang and Daridon, Antoine and Heath, James R. and Kolb, Hartmuth C. (2011) Flow optimization study of a batch microfluidics PET tracer synthesizing device. Biomedical Microdevices, 13 (1). pp. 231-242. ISSN 1387-2176 . PMCID PMC3028087. http://resolver.caltech.edu/CaltechAUTHORS:20110301-113228946

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Abstract

We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers. Novel techniques are used for mixing within, and eluting liquid out of, the coin-shaped reaction chamber. Numerical solutions of the general incompressible Navier Stokes equations along with time-dependent elution scalar field equation for the three dimensional coin-shaped geometry were obtained and validated using fluorescence imaging analysis techniques. Utilizing the approach presented in this work, we were able to identify optimized geometrical and operational conditions for the micro-reactor in the absence of radioactive material commonly used in PET related tracer production platforms as well as evaluate the designed and fabricated micro-reactor using numerical and experimental validations.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s10544-010-9488-0DOIArticle
http://www.springerlink.com/content/58761385l2066032/PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028087/PubMed CentralArticle
ORCID:
AuthorORCID
Heath, James R.0000-0001-5356-4385
Additional Information:© 2010 The Author(s). This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. Published online: 12 November 2010. This work was funded by Siemens Molecular Imaging, Biomarker Research, Culver City, CA and by the Institute for Collaborative Biotechnologies throughcontract no. W911NF-09-D-0001 from the U.S. Army Research Office. The content of the information herein does not necessarily reflect the position or policy of the Government and no official endorsement should be inferred.
Group:Kavli Nanoscience Institute
Funders:
Funding AgencyGrant Number
Siemens Molecular ImagingUNSPECIFIED
Army Research Office (ARO)W911NF-09-D-0001
Subject Keywords:Flow optimization; Microfluidic; Positron emission tomography; Fluorescence imaging; Microreactor; Numerical modeling
PubMed Central ID:PMC3028087
Record Number:CaltechAUTHORS:20110301-113228946
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20110301-113228946
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:22584
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:03 Mar 2011 15:46
Last Modified:16 Oct 2015 02:31

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