Elizarov, Arkadij M. and Meinhart, Carl and Miraghaie, Reza and van Dam, R. Michael and Huang, Jiang and Daridon, Antoine and Heath, James R. and Kolb, Hartmuth C. (2011) Flow optimization study of a batch microfluidics PET tracer synthesizing device. Biomedical Microdevices, 13 (1). pp. 231-242. ISSN 1387-2176 . PMCID PMC3028087. http://resolver.caltech.edu/CaltechAUTHORS:20110301-113228946
![]()
|
PDF
- Published Version
Creative Commons Attribution Non-commercial. 1239Kb |
Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20110301-113228946
Abstract
We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers. Novel techniques are used for mixing within, and eluting liquid out of, the coin-shaped reaction chamber. Numerical solutions of the general incompressible Navier Stokes equations along with time-dependent elution scalar field equation for the three dimensional coin-shaped geometry were obtained and validated using fluorescence imaging analysis techniques. Utilizing the approach presented in this work, we were able to identify optimized geometrical and operational conditions for the micro-reactor in the absence of radioactive material commonly used in PET related tracer production platforms as well as evaluate the designed and fabricated micro-reactor using numerical and experimental validations.
Item Type: | Article | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Related URLs: |
| ||||||||||||
ORCID: |
| ||||||||||||
Additional Information: | © 2010 The Author(s). This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. Published online: 12 November 2010. This work was funded by Siemens Molecular Imaging, Biomarker Research, Culver City, CA and by the Institute for Collaborative Biotechnologies throughcontract no. W911NF-09-D-0001 from the U.S. Army Research Office. The content of the information herein does not necessarily reflect the position or policy of the Government and no official endorsement should be inferred. | ||||||||||||
Group: | Kavli Nanoscience Institute | ||||||||||||
Funders: |
| ||||||||||||
Subject Keywords: | Flow optimization; Microfluidic; Positron emission tomography; Fluorescence imaging; Microreactor; Numerical modeling | ||||||||||||
PubMed Central ID: | PMC3028087 | ||||||||||||
Record Number: | CaltechAUTHORS:20110301-113228946 | ||||||||||||
Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:20110301-113228946 | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 22584 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Ruth Sustaita | ||||||||||||
Deposited On: | 03 Mar 2011 15:46 | ||||||||||||
Last Modified: | 16 Oct 2015 02:31 |
Repository Staff Only: item control page