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Semele: A Killer-Male, Rescue-Female System for Suppression and Replacement of Insect Disease Vector Populations

Marshall, John M. and Pittman, Geoffrey W. and Buchman, Anna B. and Hay, Bruce A. (2011) Semele: A Killer-Male, Rescue-Female System for Suppression and Replacement of Insect Disease Vector Populations. Genetics, 187 (2). pp. 535-551. ISSN 0016-6731. PMCID PMC3030495. https://resolver.caltech.edu/CaltechAUTHORS:20110307-112456736

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Abstract

Two strategies to control mosquito-borne diseases, such as malaria and dengue fever, are reducing mosquito population sizes or replacing populations with disease-refractory varieties. We propose a genetic system, Semele, which may be used for both. Semele consists of two components: a toxin expressed in transgenic males that either kills or renders infertile wild-type female recipients and an antidote expressed in females that protects them from the effects of the toxin. An all-male release results in population suppression because wild-type females that mate with transgenic males produce no offspring. A release that includes transgenic females results in gene drive since females carrying the allele are favored at high population frequencies. We use simple population genetic models to explore the utility of the Semele system. We find that Semele can spread under a wide range of conditions, all of which require a high introduction frequency. This feature is desirable since transgenic insects released accidentally are unlikely to persist, transgenic insects released intentionally can be spatially confined, and the element can be removed from a population through sustained release of wild-type insects. We examine potential barriers to Semele gene drive and suggest molecular tools that could be used to build the Semele system.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1534/genetics.110.124479 DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3030495/PublisherArticle
ORCID:
AuthorORCID
Buchman, Anna B.0000-0002-8775-6147
Additional Information:© 2011 Genetics Society of America. Available freely online through the author-supported open access option. Communicating editor: M. K. Uyenoyama. Manuscript received October 21, 2010; Accepted for publication November 10, 2010. Originally published as Genetics Advance Online Publication on November 15, 2010. The authors thank Fred Gould for helpful insight into the Semele system, Catherine Ward for helpful discussions on model design, and two anonymous reviewers whose constructive comments improved the manuscript. John M. Marshall was supported by grant DP1 OD003878 to Bruce A. Hay from the National Institutes of Health.
Funders:
Funding AgencyGrant Number
NIHDP1 OD003878
Issue or Number:2
PubMed Central ID:PMC3030495
Record Number:CaltechAUTHORS:20110307-112456736
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110307-112456736
Official Citation:Marshall, John M., Pittman, Geoffrey W., Buchman, Anna B., Hay, Bruce A. Semele: A Killer-Male, Rescue-Female System for Suppression and Replacement of Insect Disease Vector Populations Genetics 2011 187: 535-551
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:22693
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:09 Mar 2011 19:34
Last Modified:21 Apr 2020 20:29

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