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Design and self-assembly of two-dimensional DNA crystals

Winfree, Erik and Liu, Furong and Wenzler, Lisa A. and Seeman, Nadrian C. (1998) Design and self-assembly of two-dimensional DNA crystals. Nature, 394 (6693). pp. 539-544. ISSN 0028-0836. doi:10.1038/28998.

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Molecular self-assembly presents a `bottom-up' approach to the fabrication of objects specified with nanometre precision. DNA molecular structures and intermolecular interactions are particularly amenable to the design and synthesis of complex molecular objects. We report the design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules. Intermolecular interactions between the structural units are programmed by the design of `sticky ends' that associate according to Watson-Crick complementarity, enabling us to create specific periodic patterns on the nanometre scale. The patterned crystals have been visualized by atomic force microscopy.

Item Type:Article
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URLURL TypeDescription ReadCube access
Winfree, Erik0000-0002-5899-7523
Seeman, Nadrian C.0000-0002-9680-4649
Additional Information:© 1998 Nature Publishing Group. Received 10 March 1998; Accepted 5 May 1998. We thank J. Hopfield, S. Roweis, S. Mahajan, C. Brody, L. Adleman and P. Rothemund for discussion; J. Abelson and his group for use of his laboratory and for technical advice; A. Segal, E. Rabani and R. Moision for instruction and advice on AFM imaging; the Beckman Institute Molecular Materials Resource Center for assistance and use of their AFM facilities; F. Furuya for help with labelling; and M. Yoder, V. Morozov, D. Stokes, M. Simon and J. Wall for assistance in early attempts to visualize DNA lattices. The research at Caltech has been supported by the National Institute for Mental Health, General Motors' Technology Research Partnerships program, and by the Center for Neuromorphic Systems Engineering as a part of the NSF Engineering Research Center Program. The research at NYU has been supported by the Office of Naval Research, the National Institute of General Medical Sciences, and the NSF.
Funding AgencyGrant Number
National Institute of Mental Health (NIMH)UNSPECIFIED
General Motors' Technology Research PartnershipsUNSPECIFIED
Center for Neuromorphic Systems Engineering, CaltechUNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
National Institute of General Medical SciencesUNSPECIFIED
Issue or Number:6693
Record Number:CaltechAUTHORS:20110309-104205657
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:22780
Deposited By: Lucinda Acosta
Deposited On:09 Mar 2011 19:33
Last Modified:09 Nov 2021 16:08

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