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Differential electrophysiological response during rest, self-referential, and non-self-referential tasks in human posteromedial cortex

Dastjerdi, Mohammad and Foster, Brett L. and Nasrullah, Sharmin and Rauschecker, Andreas M. and Dougherty, Robert F. and Townsend, Jennifer D. and Chang, Catie and Greicius, Michael D. and Menon, Vinod and Kennedy, Daniel P. and Parvizi, Josef (2011) Differential electrophysiological response during rest, self-referential, and non-self-referential tasks in human posteromedial cortex. Proceedings of the National Academy of Sciences of the United States of America, 108 (7). pp. 3023-3028. ISSN 0027-8424. PMCID PMC3041085. https://resolver.caltech.edu/CaltechAUTHORS:20110315-102034984

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Abstract

The electrophysiological basis for higher brain activity during rest and internally directed cognition within the human default mode network (DMN) remains largely unknown. Here we use intracranial recordings in the human posteromedial cortex (PMC), a core node within the DMN, during conditions of cued rest, autobiographical judgments, and arithmetic processing. We found a heterogeneous profile of PMC responses in functional, spatial, and temporal domains. Although the majority of PMC sites showed increased broad gamma band activity (30-180 Hz) during rest, some PMC sites, proximal to the retrosplenial cortex, responded selectively to autobiographical stimuli. However, no site responded to both conditions, even though they were located within the boundaries of the DMN identified with resting-state functional imaging and similarly deactivated during arithmetic processing. These findings, which provide electrophysiological evidence for heterogeneity within the core of the DMN, will have important implications for neuroimaging studies of the DMN.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.1017098108DOIArticle
http://www.pnas.org/content/108/7/3023PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041085/PubMed CentralArticle
ORCID:
AuthorORCID
Kennedy, Daniel P.0000-0002-5915-0893
Additional Information:© 2011 National Academy of Sciences. Edited by Marcus E. Raichle, Washington University of St. Louis, St. Louis, MO, and approved December 29, 2010 (received for review November 13, 2010). Published online before print January 31, 2011. We thank the patients for participating in this study; Robert Knight and his laboratory members at the University of California, Berkeley, for their assistance with data analysis and useful comments on the manuscript; and Anthony Wagner, Brian Wandell, Bill Newsome, and their laboratory members at Stanford University for their insightful comments throughout the study. This work was supported by a grant from the Milken Family Foundation (to J.P) and by the Stanford University BioX program. Author contributions: J.P. designed research; M.D., B.L.F, S.N., A.M.R., C.C., and J.P. performed research; R.F.D., M.D.G., V.M., D.P.K., and J.P. contributed new reagents/analytic tools; M.D., B.L.F., S.N., A.M.R., J.D.T., and J.P. analyzed data; and M.D., B.L.F., and J.P. wrote the paper.
Funders:
Funding AgencyGrant Number
Milken Family Foundation UNSPECIFIED
Stanford University UNSPECIFIED
Subject Keywords:electrocorticography; oscillations; posterior cingulate; precuneus
Issue or Number:7
PubMed Central ID:PMC3041085
Record Number:CaltechAUTHORS:20110315-102034984
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110315-102034984
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:22897
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Mar 2011 21:11
Last Modified:03 Oct 2019 02:41

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