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Assembling Neural Crest Regulatory Circuits into a Gene Regulatory Network

Betancur, Paola and Sauka-Spengler, Tatjana and Bronner-Fraser, Marianne (2010) Assembling Neural Crest Regulatory Circuits into a Gene Regulatory Network. Annual Review of Cell and Developmental Biology, 26 . pp. 581-603. ISSN 1081-0706. PMCID PMC4040144. https://resolver.caltech.edu/CaltechAUTHORS:20110321-093844927

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Abstract

The neural crest is a multipotent stem cell–like population that gives rise to a wide range of derivatives in the vertebrate embryo including elements of the craniofacial skeleton and peripheral nervous system as well as melanocytes. The neural crest forms in a series of regulatory steps that include induction and specification of the prospective neural crest territory–neural plate border, specification of bona fide neural crest progenitors, and differentiation into diverse derivatives. These individual processes during neural crest ontogeny are controlled by regulatory circuits that can be assembled into a hierarchical gene regulatory network (GRN). Here we present an overview of the GRN that orchestrates the formation of cranial neural crest cells. Formulation of this network relies on information largely inferred from gene perturbation studies performed in several vertebrate model organisms. Our representation of the cranial neural crest GRN also includes information about direct regulatory interactions obtained from the cis-regulatory analyses performed to date, which increases the resolution of the architectural circuitry within the network.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1146/annurev.cellbio.042308.113245 DOIArticle
http://www.annualreviews.org/doi/abs/10.1146/annurev.cellbio.042308.113245PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040144/PubMed CentralArticle
ORCID:
AuthorORCID
Sauka-Spengler, Tatjana0000-0001-9289-0263
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2010 by Annual Reviews. First published online as a Review in Advance on June 29, 2010.
Subject Keywords:stem cell; transcription factors; cell migration; cis-regulation
PubMed Central ID:PMC4040144
Record Number:CaltechAUTHORS:20110321-093844927
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110321-093844927
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23005
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Mar 2011 20:44
Last Modified:09 Mar 2020 13:19

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