Stark, Chris and Breitkreutz, Bobby-Joe and Chatr-aryamontri, Andrew and Boucher, Lorrie and Oughtred, Rose and Livstone, Michael S. and Nixon, Julie and Van Auken, Kimberly and Wang, Xiaodong and Shi, Xiaoqi and Reguly, Teresa and Rust, Jennifer M. and Winter, Andrew and Dolinski, Kara and Tyers, Mike (2011) The BioGRID Interaction Database: 2011 update. Nucleic Acids Research, 39 (Supple). D698-D704. ISSN 0305-1048. PMCID PMC3013707. https://resolver.caltech.edu/CaltechAUTHORS:20110322-093738471
![]()
|
PDF
- Published Version
Creative Commons Attribution Non-commercial. 4Mb |
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20110322-093738471
Abstract
The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein interaction data from model organisms and humans (http://www.thebiogrid.org). BioGRID currently holds 347 966 interactions (170 162 genetic, 177 804 protein) curated from both high-throughput data sets and individual focused studies, as derived from over 23 000 publications in the primary literature. Complete coverage of the entire literature is maintained for budding yeast (Saccharomyces cerevisiae), fission yeast (Schizosaccharomyces pombe) and thale cress (Arabidopsis thaliana), and efforts to expand curation across multiple metazoan species are underway. The BioGRID houses 48 831 human protein interactions that have been curated from 10 247 publications. Current curation drives are focused on particular areas of biology to enable insights into conserved networks and pathways that are relevant to human health. The BioGRID 3.0 web interface contains new search and display features that enable rapid queries across multiple data types and sources. An automated Interaction Management System (IMS) is used to prioritize, coordinate and track curation across international sites and projects. BioGRID provides interaction data to several model organism databases, resources such as Entrez-Gene and other interaction meta-databases. The entire BioGRID 3.0 data collection may be downloaded in multiple file formats, including PSI MI XML. Source code for BioGRID 3.0 is freely available without any restrictions.
Item Type: | Article | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Related URLs: |
| ||||||||||||||||||
ORCID: |
| ||||||||||||||||||
Additional Information: | © The Author(s) 2010. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors. Received September 30, 2010; Revised October 18, 2010; Accepted October 19, 2010. First published online: November 11, 2010. We thank Mike Cherry, Paul Sternberg, Bill Gelbart, Gary Bader, Quaid Morris, Olga Troyanskaya, David Botstein, Henning Hermjakob, Shoshana Wodak, Ian Donaldson, Anne-Claude Gingras, Val Wood, Jurg Bahler, Lincoln Stein and Judy Blake for support and helpful discussions. | ||||||||||||||||||
Funders: |
| ||||||||||||||||||
Issue or Number: | Supple | ||||||||||||||||||
PubMed Central ID: | PMC3013707 | ||||||||||||||||||
Record Number: | CaltechAUTHORS:20110322-093738471 | ||||||||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20110322-093738471 | ||||||||||||||||||
Usage Policy: | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | ||||||||||||||||||
ID Code: | 23041 | ||||||||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||||||||
Deposited By: | Tony Diaz | ||||||||||||||||||
Deposited On: | 22 Mar 2011 21:59 | ||||||||||||||||||
Last Modified: | 03 Oct 2019 02:42 |
Repository Staff Only: item control page