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Biological water: A critique

Zhong, Dongping and Pal, Samir Kumar and Zewail, Ahmed H. (2011) Biological water: A critique. Chemical Physics Letters, 503 (1-3). pp. 1-11. ISSN 0009-2614.

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In this overview, we provide a critique of the hydration dynamics of macromolecules, particularly those of protein and DNA. Only in the past decade has femtosecond spectroscopy enabled direct access to the ultrafast dynamical motion of surface water. With the wealth of results from this spectroscopic technique, NMR, and neutron scattering, it is now established that hydration is indeed an ultrafast phenomenon, and in this sense the ‘iceberg model’ is invalid. Here, we overview the experimental and the theoretical studies, hoping to clarify the confusion resulting from some recent MD simulations. We maintain that there are two types of water hydration, those that reorient in the vicinity of the surface and those which are ordered, however in dynamic interaction with the protein.

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Additional Information:© 2010 Elsevier B.V. Received 23 December 2010; accepted 24 December 2010. Available online 29 December 2010. DZ and SKP thank Prof. Ahmed H. Zewail for the generous hospitality during a sabbatical stay, which enabled this work to be completed. DZ likes to thank Profs. Wolfgang Doster and Songi Han for their helpful discussion. The work was supported in part by the National Science Foundation (CHE0748358) and the Packard fellowship to DZ, and by the National Science Foundation (DMR-0964886) to AZ.
Funding AgencyGrant Number
David and Lucile Packard FoundationUNSPECIFIED
NSF DMR-0964886
Issue or Number:1-3
Record Number:CaltechAUTHORS:20110328-080820919
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Official Citation:Dongping Zhong, Samir Kumar Pal, Ahmed H. Zewail, Biological water: A critique, Chemical Physics Letters, Volume 503, Issues 1–3, 8 February 2011, Pages 1-11, ISSN 0009-2614, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23114
Deposited By: Ruth Sustaita
Deposited On:28 Mar 2011 20:25
Last Modified:03 Oct 2019 02:43

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