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Evolution of Gene Regulatory Networks Controlling Body Plan Development

Peter, Isabelle S. and Davidson, Eric H. (2011) Evolution of Gene Regulatory Networks Controlling Body Plan Development. Cell, 144 (6). pp. 970-985. ISSN 0092-8674. PMCID PMC3076009. http://resolver.caltech.edu/CaltechAUTHORS:20110401-113748264

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Abstract

Evolutionary change in animal morphology results from alteration of the functional organization of the gene regulatory networks (GRNs) that control development of the body plan. A major mechanism of evolutionary change in GRN structure is alteration of cis-regulatory modules that determine regulatory gene expression. Here we consider the causes and consequences of GRN evolution. Although some GRN subcircuits are of great antiquity, other aspects are highly flexible and thus in any given genome more recent. This mosaic view of the evolution of GRN structure explains major aspects of evolutionary process, such as hierarchical phylogeny and discontinuities of paleontological change.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.cell.2011.02.017DOIArticle
http://www.sciencedirect.com/science/article/pii/S0092867411001310PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076009/PubMed CentralArticle
ORCID:
AuthorORCID
Peter, Isabelle S.0000-0003-3685-3147
Additional Information:© 2011 Elsevier Inc. Available online 17 March 2011. We gratefully acknowledge support for this work from NIH Grant HD-037105 and from NSF Grant IOS-0641398.
Funders:
Funding AgencyGrant Number
NIHHD-037105
NSFIOS-0641398
PubMed Central ID:PMC3076009
Record Number:CaltechAUTHORS:20110401-113748264
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20110401-113748264
Official Citation:Isabelle S. Peter, Eric H. Davidson, Evolution of Gene Regulatory Networks Controlling Body Plan Development, Cell, Volume 144, Issue 6, 18 March 2011, Pages 970-985, ISSN 0092-8674, DOI: 10.1016/j.cell.2011.02.017.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23205
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:01 Apr 2011 20:31
Last Modified:28 Jun 2017 18:35

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