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Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement

Paul, Lynn K. (2011) Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement. Journal of Neurodevelopmental Disorders, 3 (1). pp. 3-27. ISSN 1866-1947. PMCID PMC3163989. https://resolver.caltech.edu/CaltechAUTHORS:20110404-100257854

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Abstract

This review provides an overview of the involvement of the corpus callosum (CC) in a variety of developmental disorders that are currently defined exclusively by genetics, developmental insult, and/or behavior. I begin with a general review of CC development, connectivity, and function, followed by discussion of the research methods typically utilized to study the callosum. The bulk of the review concentrates on specific developmental disorders, beginning with agenesis of the corpus callosum (AgCC)—the only condition diagnosed exclusively by callosal anatomy. This is followed by a review of several genetic disorders that commonly result in social impairments and/or psychopathology similar to AgCC (neurofibromatosis-1, Turner syndrome, 22q11.2 deletion syndrome, Williams yndrome, and fragile X) and two forms of prenatal injury (premature birth, fetal alcohol syndrome) known to impact callosal development. Finally, I examine callosal involvement in several common developmental disorders defined exclusively by behavioral patterns (developmental language delay, dyslexia, attention-deficit hyperactive disorder, autism spectrum disorders, and Tourette syndrome).


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/s11689-010-9059-yDOIArticle
http://www.springerlink.com/content/y54113544761282v/PublisherArticle
https://www.ncbi.nlm.nih.gov/pubmed/21484594PubMed CentralArticle
ORCID:
AuthorORCID
Paul, Lynn K.0000-0002-3128-8313
Additional Information:© 2010 Springer Science, LLC. Received: 1 June 2010. Accepted: 13 August 2010. Published online: 23 September 2010. I am extremely grateful to Ralph Adolphs for helpful comments on this review. Supported in part by grants from National Institutes of Health and the Simons Foundation.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Simons FoundationUNSPECIFIED
Subject Keywords:Corpus callosum; White matter; Brain connectivity; Neuroanatomy; Interhemispheric
Issue or Number:1
PubMed Central ID:PMC3163989
Record Number:CaltechAUTHORS:20110404-100257854
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110404-100257854
Official Citation:Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement Lynn K. Paul
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23226
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:10 Apr 2011 01:26
Last Modified:03 Oct 2019 02:44

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