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PIWI-interacting small RNAs: the vanguard of genome defence

Siomi, Mikiko C. and Sato, Kaoru and Pezic, Dubravka and Aravin, Alexei A. (2011) PIWI-interacting small RNAs: the vanguard of genome defence. Nature Reviews. Molecular Cell Biology, 12 (4). pp. 246-258. ISSN 1471-0072. https://resolver.caltech.edu/CaltechAUTHORS:20110414-105630858

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Abstract

PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that form the piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The piRISC protects the integrity of the genome from invasion by 'genomic parasites' — transposable elements — by silencing them. Owing to their limited expression in gonads and their sequence diversity, piRNAs have been the most mysterious class of small non-coding RNAs regulating RNA silencing. Now, much progress is being made into our understanding of their biogenesis and molecular functions, including the specific subcellular compartmentalization of the piRNA pathway in granular cytoplasmic bodies.


Item Type:Article
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http://dx.doi.org/10.1038/nrm3089DOIArticle
http://www.nature.com/nrm/journal/v12/n4/full/nrm3089.htmlPublisherArticle
http://rdcu.be/d3psPublisherFree ReadCube access
Additional Information:© 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. Published online 23 March 2011. We thank H. Siomi, A. Nagao, A. Webster, N. Perkins and I. Olovnikov for comments on the manuscript. The work in the laboratory of M.C.S. is supported by Ministry of Education, Culture, Sports, Science and Technology (MEXT) grants to K.S. and M.C.S. M.C.S. is supported by the Core Research for Evolutional Science and Technology (CREST) programme of the Japan Science and Technology Agency (JST). The work in the laboratory of A.A.A. is supported by the US National Institutes of Health (grants DP2 OD007371A and R00 HD057233‑02 to A.A.A.) and the Ellison Medical Foundation.
Funders:
Funding AgencyGrant Number
Ministry of Education, Culture, Sports, Science and Technology (MEXT)UNSPECIFIED
Japan Science and Technology Agency (JST) Core Research for Evolutional Science and Technology (CREST)UNSPECIFIED
NIHDP2 OD007371A
NIHR00 HD057233‑02
Ellison Medical FoundationUNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:20110414-105630858
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110414-105630858
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23340
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:14 Apr 2011 18:27
Last Modified:03 Oct 2019 02:45

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