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Overlapping Responses for the Expectation of Juice and Money Rewards in Human Ventromedial Prefrontal Cortex

Kim, Hackjin and Shimojo, Shinsuke and O'Doherty, John P. (2011) Overlapping Responses for the Expectation of Juice and Money Rewards in Human Ventromedial Prefrontal Cortex. Cerebral Cortex, 21 (4). pp. 769-776. ISSN 1047-3211.

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Although much is known about the neural substrates of reward, the question of whether expectation of different types of reinforcers engage distinct or overlapping brain circuitry has not been addressed definitively. In the present study, human subjects, while being scanned with functional magnetic resonance imaging, performed a simple reward-based action selection task to obtain different magnitudes of either monetary outcomes (winning or losing money) or juice outcomes (pleasant apple juice or an unpleasant salt flavor). At the group level, we found partially overlapping value-related activity within ventromedial prefrontal cortex (vmPFC) during anticipation of juice and money reward outcomes. Analogous results were found in the right anterior insula, except that this region showed negative correlations as a function of increasing expected reward. These results indicate that vmPFC and anterior insula contain overlapping representations of anticipatory value, consistent with the existence of a common currency for the value of expected outcomes in these regions.

Item Type:Article
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URLURL TypeDescription
Shimojo, Shinsuke0000-0002-1290-5232
O'Doherty, John P.0000-0003-0016-3531
Additional Information:© 2010 The Author. Published by Oxford University Press. First published online: August 23, 2010. Funding: National Science Foundation grant (0617174) and Searle Scholarship (to J.P.O.D.); Japan Science and Technology Agency, Exploratory Research for Advanced Technology (to S.S.); the Gordon and Betty Moore Foundation (to J.P.O.D.); World Class University program through the Korea Science and Engineering Foundation funded by the Ministry of Education, Science and Technology (R31-2008-000-10008-0 to H.K.). We thank Po-Yin Samuel Huang, Tony Bruguier, and Shawn Wagner for technical assistance. Conflict of Interest: None declared.
Funding AgencyGrant Number
Searle Scholars ProgramUNSPECIFIED
Japan Science and Technology AgencyUNSPECIFIED
Gordon and Betty Moore FoundationUNSPECIFIED
Ministry of Education, Science and Technology (Korea)R31-2008-000-10008-0
Subject Keywords:fMRI; insula; juice; value; vmPFC
Issue or Number:4
Record Number:CaltechAUTHORS:20110415-105904156
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23345
Deposited By: Tony Diaz
Deposited On:17 May 2011 22:34
Last Modified:22 Oct 2020 19:23

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