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Effects of visual stimulation on LFPs, spikes, and LFP-spike relations in PRR

Hwang, Eun Jung and Andersen, Richard A. (2011) Effects of visual stimulation on LFPs, spikes, and LFP-spike relations in PRR. Journal of Neurophysiology, 105 (4). pp. 1850-1860. ISSN 0022-3077. PMCID PMC3075288. doi:10.1152/jn.00802.2010.

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Local field potentials (LFPs) have shown diverse relations to the spikes across different brain areas and stimulus features, suggesting that LFP-spike relationships are highly specific to the underlying connectivity of a local network. If so, the LFP-spike relationship may vary even within one brain area under the same task condition if neurons have heterogeneous connectivity with the active input sources during the task. Here, we tested this hypothesis in the parietal reach region (PRR), which includes two distinct classes of motor goal planning neurons with different connectivity to the visual input, i.e., visuomotor neurons receive stronger visual input than motor neurons. We predicted that the visual stimulation would render both the spike response and the LFP-spike relationship different between the two neuronal subpopulations. Thus we examined how visual stimulations affect spikes, LFPs, and LFP-spike relationships in PRR by comparing their planning (delay) period activity between two conditions: with or without a visual stimulus at the reach target. Neurons were classified as visuomotor if the visual stimulation increased their firing rate, or as motor otherwise. We found that the visual stimulation increased LFP power in gamma bands >40 Hz for both classes. Moreover, confirming our prediction, the correlation between the LFP gamma power and the firing rate became higher for the visuomotor than motor neurons in the presence of visual stimulation. We conclude that LFPs vary with the stimulation condition and that the LFP-spike relationship depends on a given neuron’s connectivity to the dominant input sources in a particular stimulation condition.

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URLURL TypeDescription CentralArticle
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2011 American Physiological Society. Submitted 20 September 2010; accepted in final form 6 February 2011. First published February 9, 2011. We thank Chess Stetson and Drs. Igor Kagan, Melanie Wilke, and Alexander Gail for scientific discussion; Tessa Yao for editorial assistance; Kelsie Pejsa and Nicole Simmons for animal care: and Viktor Shcherbatyuk for technical assistance. This work was supported by National Eye Institute Grant EY-013337. E. J. Hwang was supported by NIH Research Service Award T32 NS007251 and Career Development Award K99 NS062894.
Funding AgencyGrant Number
NIH Predoctoral FellowshipT32 NS007251
NIHK99 NS062894
National Eye InstituteUNSPECIFIED
Subject Keywords:local field potential-spike correlation; parietal reach region; gamma band; visuomotor and motor neurons; parietal cortex; bottom-up and top-down input; reaches
Issue or Number:4
PubMed Central ID:PMC3075288
Record Number:CaltechAUTHORS:20110425-082707562
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23442
Deposited By: Tony Diaz
Deposited On:25 Apr 2011 16:38
Last Modified:09 Nov 2021 16:14

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