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Long-Range Interaction between Heterogeneously Charged Membranes

Jho, Y. S. and Brewster, R. and Safran, S. A. and Pincus, P. A. (2011) Long-Range Interaction between Heterogeneously Charged Membranes. Langmuir, 27 (8). pp. 4439-4446. ISSN 0743-7463. https://resolver.caltech.edu/CaltechAUTHORS:20110502-091911074

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Abstract

Despite their neutrality, surfaces or membranes with equal amounts of positive and negative charge can exhibit long-range electrostatic interactions if the surface charge is heterogeneous; this can happen when the surface charges form finite-size domain structures. These domains can be formed in lipid membranes where the balance of the different ranges of strong but short-ranged hydrophobic interactions and longer-ranged electrostatic repulsion result in a finite, stable domain size. If the domain size is large enough, oppositely charged domains in two opposing surfaces or membranes can be strongly correlated by the elecrostatic interactions; these correlations give rise to an attractive interaction of the two membranes or surfaces over separations on the order of the domain size. We use numerical simulations to demonstrate the existence of strong attractions at separations of tens of nanometers. Large line tensions result in larger domains but also increase the charge density within the domain. This promotes correlations and, as a result, increases the intermembrane attraction. On the other hand, increasing the salt concentration increases both the domain size and degree of domain anticorrelation, but the interactions are ultimately reduced due to increased screening. The result is a decrease in the net attraction as salt concentration is increased.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/la1050282DOIUNSPECIFIED
http://pubs.acs.org/doi/abs/10.1021/la1050282PublisherUNSPECIFIED
Additional Information:© 2011 American Chemical Society. Received: December 20, 2010. Revised: February 16, 2011. Published: March 16, 2011. S.A.S. and P.A.P. are grateful to the U.S. Israel Binational Science Foundation for their support. S.A.S. thanks the Perlman Family Foundation for its historical generosity and partial support. P.A.P. was supported by the WCU (World Class University) program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology No. R33-2008-000-10163-0 and the National Science Foundation Grant NSF-DMR 0803103. This work was partially supported by the IMI Program of the National Science Foundation under Award No. DMR04-09848. The calculations were performed using the SGI Altix3700Bx2 at the Advanced Fluid Information Research Center, Institute of Fluid Science, Tohoku University.
Funders:
Funding AgencyGrant Number
U.S.-Israel Binational Science Foundation UNSPECIFIED
National Research Foundation of Korea Ministry of Education, Science and TechnologyR33-2008-000-10163-0
NSFDMR 0803103
NSF IMI Program DMR 04-09848
Perlman Family Foundation UNSPECIFIED
Issue or Number:8
Record Number:CaltechAUTHORS:20110502-091911074
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110502-091911074
Official Citation:Long-Range Interaction between Heterogeneously Charged Membranes Y. S. Jho, R. Brewster, S. A. Safran, P. A. Pincus Langmuir 2011 27 (8), 4439-4446
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23513
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 May 2011 17:03
Last Modified:03 Oct 2019 02:47

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