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Single-Step Charge Transport through DNA over Long Distances

Genereux, Joseph C. and Wuerth, Stephanie M. and Barton, Jacqueline K. (2011) Single-Step Charge Transport through DNA over Long Distances. Journal of the American Chemical Society, 133 (11). pp. 3863-3868. ISSN 0002-7863. PMCID PMC3079569. doi:10.1021/ja107033v. https://resolver.caltech.edu/CaltechAUTHORS:20110502-100301067

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Abstract

Quantum yields for charge transport across adenine tracts of increasing length have been measured by monitoring hole transport in synthetic oligonucleotides between photoexcited 2-aminopurine, a fluorescent analogue of adenine, and N_2-cyclopropyl guanine. Using fluorescence quenching, a measure of hole injection, and hole trapping by the cyclopropyl guanine derivative, we separate the individual contributions of single- and multistep channels to DNA charge transport and find that with 7 or 8 intervening adenines the charge transport is a coherent, single-step process. Moreover, a transition occurs from multistep to single-step charge transport with increasing donor/acceptor separation, opposite to that generally observed in molecular wires. These results establish that coherent transport through DNA occurs preferentially across 10 base pairs, favored by delocalization over a full turn of the helix.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja107033vDOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079569/PubMed CentralArticle
ORCID:
AuthorORCID
Genereux, Joseph C.0000-0002-5093-7710
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2011 American Chemical Society. Received: August 5, 2010. Published: February 24, 2011. We are grateful to the National Institutes of Health (GM49216) for their support. We also thank the Caltech SURF program for a summer undergraduate fellowship (S.M.W.).
Funders:
Funding AgencyGrant Number
NIHGM49216
Caltech Summer Undergraduate Research Fellowship (SURF)UNSPECIFIED
Issue or Number:11
PubMed Central ID:PMC3079569
DOI:10.1021/ja107033v
Record Number:CaltechAUTHORS:20110502-100301067
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110502-100301067
Official Citation:Single-Step Charge Transport through DNA over Long Distances Joseph C. Genereux, Stephanie M. Wuerth, Jacqueline K. Barton Journal of the American Chemical Society 2011 133 (11), 3863-3868
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23515
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 May 2011 17:26
Last Modified:09 Nov 2021 16:15

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