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Targeting kidney mesangium by nanoparticles of defined size

Choi, Chung Hang J. and Zuckerman, Jonathan E. and Webster, Paul and Davis, Mark E. (2011) Targeting kidney mesangium by nanoparticles of defined size. Proceedings of the National Academy of Sciences of the United States of America, 108 (16). pp. 6656-6661. ISSN 0027-8424. PMCID PMC3080986. doi:10.1073/pnas.1103573108. https://resolver.caltech.edu/CaltechAUTHORS:20110506-112052601

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Abstract

Nanoparticles are being investigated for numerous medical applications and are showing potential as an emerging class of carriers for drug delivery. Investigations on how the physicochemical properties (e.g., size, surface charge, shape, and density of targeting ligands) of nanoparticles enable their ability to overcome biological barriers and reach designated cellular destinations in sufficient amounts to elicit biological efficacy are of interest. Despite proven success in nanoparticle accumulation at cellular locations and occurrence of downstream therapeutic effects (e.g., target gene inhibition) in a selected few organs such as tumor and liver, reports on effective delivery of engineered nanoparticles to other organs still remain scarce. Here, we show that nanoparticles of ~75 ± 25-nm diameters target the mesangium of the kidney. These data show the effects of particle diameter on targeting the mesangium of the kidney. Because many diseases originate from this area of the kidney, our findings establish design criteria for constructing nanoparticle-based therapeutics for targeting diseases that involve the mesangium of the kidney.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.1103573108 DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3080986/PubMed CentralArticle
ORCID:
AuthorORCID
Davis, Mark E.0000-0001-8294-1477
Additional Information:© 2011 National Academy of Sciences. Freely available online through the PNAS open access option. Contributed by Mark E. Davis, March 7, 2011 (sent for review February 8, 2011). We thank Debbie Guerrero and Siva Wu from the House Ear Institute for advice in histology. This work was supported by National Cancer Institute Grant CA119347 and National Institutes of Health Grant NIH 2P30DC006272-06 and the Ahmanson Foundation.
Funders:
Funding AgencyGrant Number
NIHCA119347
NIH2P30DC006272-06
Ahmanson FoundationUNSPECIFIED
Subject Keywords:gold nanoparticles; kidney targeting; mesangial cells; particle size
Issue or Number:16
PubMed Central ID:PMC3080986
DOI:10.1073/pnas.1103573108
Record Number:CaltechAUTHORS:20110506-112052601
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110506-112052601
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23578
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:06 May 2011 20:29
Last Modified:09 Nov 2021 16:16

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