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Parylene-based integrated wireless single-channel neurostimulator

Li, Wen and Rodger, Damien C. and Pinto, Anderson and Meng, Ellis and Weiland, James D. and Humayun, Mark S. and Tai, Yu-Chong (2011) Parylene-based integrated wireless single-channel neurostimulator. Sensors and Actuators A, 166 (2). pp. 193-200. ISSN 0924-4247.

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This paper presents the design, fabrication, and functional testing of a fully implantable, flexible, Parylene-enable neurostimulator that features single-channel wireless stimulation capability [1]. This system comprises a fold-and-bond microelectromechanical systems (MEMS) coil for wireless power and data transmission, a BION 1-3 CMOS stimulator chip, discrete capacitors, as well as a carrier substrate with two platinum stimulating electrodes and interconnections for system assembly. The physical geometries of the devices are designed for use in retinal implantation with the specifications determined from the implantation results in canine eyes. The coil and carrier substrate are separately fabricated using a Parylene–metal skin technology. The unique properties of Parylene C allow these MEMS devices to be flexible and biocompatible, facilitating surgical procedure. The system assembly is achieved by interconnecting individual components together on the carrier substrate with a biocompatible silver epoxy. A 10 μm layer of Parylene C is selectively deposited on the integrated system to protect it from corrosive eye environment. The system functionality is verified using a telemetry link setup, and single-phase pulses with amplitudes ranging from 7 to 8.5 V are detected.

Item Type:Article
Related URLs:
URLURL TypeDescription
Rodger, Damien C.0000-0002-1583-5946
Humayun, Mark S.0000-0002-5830-5208
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2010 Elsevier B.V. Received 15 April 2009; Received in revised form 28 November 2009; Accepted 4 March 2010; Available online 16 March 2010. This work is supported in part by the Engineering Research Center Program of the National Science Foundation under Award Number EEC-0310723 and by a fellowship from the Whitaker Foundation (D.R.). The authors would like to thank Dr. Gerald Loeb and his group members for providing BION chips and testing units. My gratitude also goes to Mr. Trevor Roper and all other members of the Caltech Micromachining Laboratory for assistance with equipment and fabrication.
Funding AgencyGrant Number
NSF Engineering Research Center ProgramEEC-0310723
Whitaker FoundationUNSPECIFIED
Subject Keywords:BIONs; Implantable MEMS; Integrated neurostimulator; Parylene C; Retinal prosthesis; Wireless
Issue or Number:2
Record Number:CaltechAUTHORS:20110506-112304271
Persistent URL:
Official Citation:Wen Li, Damien C. Rodger, Anderson Pinto, Ellis Meng, James D. Weiland, Mark S. Humayun, Yu-Chong Tai, Parylene-based integrated wireless single-channel neurostimulator, Sensors and Actuators A: Physical, Volume 166, Issue 2, 22 nd IEEE International Conference on Micro Electro Mechanical Systems,Sorrento, Italy, 25-29 January 2009 - MEMS 2009, April 2011, Pages 193-200, ISSN 0924-4247, DOI: 10.1016/j.sna.2010.03.003.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23580
Deposited By: Jason Perez
Deposited On:06 May 2011 20:22
Last Modified:09 Mar 2020 13:19

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