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Regeneration in plants and animals: dedifferentiation, transdifferentiation, or just differentiation?

Sugimoto, Kaoru and Gordon, Sean P. and Meyerowitz, Elliot M. (2011) Regeneration in plants and animals: dedifferentiation, transdifferentiation, or just differentiation? Trends in Cell Biology, 21 (4). pp. 212-218. ISSN 0962-8924. https://resolver.caltech.edu/CaltechAUTHORS:20110519-081703858

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Abstract

The textbooks and literature of plant biology indicate that plant cells are totipotent, and that regeneration occurs via dedifferentiation, by which the cell and its descendents recapitulate earlier stages of development. However, recent work on the generation of callus, a presumed undifferentiated or dedifferentiated and disorganized cellular mass, indicates that the cells of callus are neither, and that callus forms predominantly from a pre-existing population of stem cells. Recent work in animal regeneration, for example in salamander limbs, also indicates that previous assumptions about the extent of dedifferentiation and pluripotency in animals are in need of critical reassessment. We review here some of these data, compare plant and animal regeneration, and argue that the importance of dedifferentiation and plasticity in regenerating systems is due for reevaluation.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.tcb.2010.12.004DOIArticle
http://www.sciencedirect.com/science/article/pii/S0962892410002722PublisherArticle
ORCID:
AuthorORCID
Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 2010 Elsevier Ltd. Available online 13 January 2011. This work was supported by the National Science Foundation (Grant IOS-0846192 to EMM) and the Japan Society for the Promotion of Science (to KS). We thank members of the Meyerowitz lab for comments on the manuscript.
Funders:
Funding AgencyGrant Number
NSFIOS-0846192
Japan Society for the Promotion of Science (JSPS)UNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:20110519-081703858
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110519-081703858
Official Citation:Kaoru Sugimoto, Sean P. Gordon, Elliot M. Meyerowitz, Regeneration in plants and animals: dedifferentiation, transdifferentiation, or just differentiation?, Trends in Cell Biology, Volume 21, Issue 4, April 2011, Pages 212-218, ISSN 0962-8924, DOI: 10.1016/j.tcb.2010.12.004. http://www.sciencedirect.com/science/article/pii/S0962892410002722
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23723
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 May 2011 22:33
Last Modified:03 Oct 2019 02:49

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