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Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses

Miwa, Julie M. and Freedman, Robert and Lester, Henry A. (2011) Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses. Neuron, 70 (1). pp. 20-33. ISSN 0896-6273. PMCID PMC4418790. doi:10.1016/j.neuron.2011.03.014.

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Cholinergic neurons and nicotinic acetylcholine receptors (nAChRs) in the brain participate in diverse functions: reward, learning and memory, mood, sensory processing, pain, and neuroprotection. Nicotinic systems also have well-known roles in drug abuse. Here, we review recent insights into nicotinic function, linking exogenous and endogenous manipulations of nAChRs to alterations in synapses, circuits, and behavior. We also discuss how these contemporary advances can motivate attempts to exploit nicotinic systems therapeutically in Parkinson's disease, cognitive decline, epilepsy, and schizophrenia.

Item Type:Article
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URLURL TypeDescription CentralArticle
Lester, Henry A.0000-0002-5470-5255
Additional Information:© 2011 Elsevier B.V. Available online 13 April 2011. We thank William Proctor and Susan Moriguchi for help with Figure 2 and T.K. Hensch, T.N. Wiesel, and R.L. Parker for helpful discussions. We received support from AG-33954, DA-11729, MH-86386, NS-11756, and the California Tobacco-Related Disease Research Program (17RT-0127, 19KT-0032). J.M.M. is founder and shareholder of Ophidion, Inc. She has applied for U.S. patents 10322359 and 20080221013, on the use of lynx for therapeutic purposes. R.F. has received U.S. patent 10322359 on the use of alpha7 nAChR sequence variants in schizophrenia diagnosis. H.A.L. has received U.S. patent 6753456 on mice with hypersenitive alpha4 nicotinic receptors.
Funding AgencyGrant Number
California Tobacco-Related Disease Research Program17RT-0127
California Tobacco-Related Disease Research Program19KT-0032
Issue or Number:1
PubMed Central ID:PMC4418790
Record Number:CaltechAUTHORS:20110519-095350891
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Official Citation:Julie M. Miwa, Robert Freedman, Henry A. Lester, Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses, Neuron, Volume 70, Issue 1, 14 April 2011, Pages 20-33, ISSN 0896-6273, DOI: 10.1016/j.neuron.2011.03.014. (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23728
Deposited By: Tony Diaz
Deposited On:19 May 2011 21:24
Last Modified:09 Nov 2021 16:17

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