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Modeling Autistic Features in Animals

Patterson, Paul H. (2011) Modeling Autistic Features in Animals. Pediatric Research, 69 (5). 34R-40R. ISSN 0031-3998. PMCID PMC3088489. http://resolver.caltech.edu/CaltechAUTHORS:20110520-105854122

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Abstract

A variety of features of autism can be simulated in rodents, including the core behavioral hallmarks of stereotyped and repetitive behaviors, and deficits in social interaction and communication. Other behaviors frequently found in autism spectrum disorders (ASDs) such as neophobia, enhanced anxiety, abnormal pain sensitivity and eye blink conditioning, disturbed sleep patterns, seizures, and deficits in sensorimotor gating are also present in some of the animal models. Neuropathology and some characteristic neurochemical changes that are frequently seen in autism, and alterations in the immune status in the brain and periphery are also found in some of the models. Several known environmental risk factors for autism have been successfully established in rodents, including maternal infection and maternal valproate administration. Also under investigation are a number of mouse models based on genetic variants associated with autism or on syndromic disorders with autistic features. This review briefly summarizes recent developments in this field, highlighting models with face and/or construct validity, and noting the potential for investigation of pathogenesis, and early progress toward clinical testing of potential therapeutics. Wherever possible, reference is made to reviews rather than to primary articles.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1203/PDR.0b013e318212b80fDOIArticle
http://journals.lww.com/pedresearch/Fulltext/2011/05020/Modeling_Autistic_Features_in_Animals.6.aspxPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088489/PubMed CentralArticle
Additional Information:© 2011 International Pediatric Research Foundation, Inc. Received January 3, 2011; accepted January 13, 2011. Autism-related research in the author’s laboratory is currently supported by the National Institute of Mental Health (R01 MH079299, EUREKA MH086781, ARRA MH088879, P50 MH086383), and the Binational Science, International Rett Syndrome, Simons, and Autism Speaks Foundations.
Funders:
Funding AgencyGrant Number
National Institute of Mental Health (NIMH)R01 MH079299
National Institute of Mental Health (NIMH)EUREKA MH086781
National Institute of Mental Health (NIMH)ARRA MH088879
National Institute of Mental Health (NIMH)P50 MH086383
Binational Science Foundation (USA-Israel)UNSPECIFIED
International Rett Syndrome FoundationUNSPECIFIED
Simons FoundationUNSPECIFIED
Autism SpeaksUNSPECIFIED
PubMed Central ID:PMC3088489
Record Number:CaltechAUTHORS:20110520-105854122
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20110520-105854122
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23750
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Jun 2011 18:33
Last Modified:30 Dec 2015 22:09

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