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Minimum Energy Path to Membrane Pore Formation and Rupture

Ting, Christina L. and Appelö, Daniel and Wang, Zhen-Gang (2011) Minimum Energy Path to Membrane Pore Formation and Rupture. Physical Review Letters, 106 (16). Art. No. 168101. ISSN 0031-9007. doi:10.1103/PhysRevLett.106.168101. https://resolver.caltech.edu/CaltechAUTHORS:20110525-082556253

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Abstract

We combine dynamic self-consistent field theory with the string method to calculate the minimum energy path to membrane pore formation and rupture. In the regime where nucleation can occur on experimentally relevant time scales, the structure of the critical nucleus is between a solvophilic stalk and a locally thinned membrane. Classical nucleation theory fails to capture these molecular details and significantly overestimates the free energy barrier. Our results suggest that thermally nucleated rupture may be an important factor for the low rupture strains observed in lipid membranes.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1103/PhysRevLett.106.168101DOIArticle
http://prl.aps.org/abstract/PRL/v106/i16/e168101PublisherArticle
ORCID:
AuthorORCID
Wang, Zhen-Gang0000-0002-3361-6114
Additional Information:© 2011 American Physical Society. Received 12 January 2011; published 18 April 2011. This work was supported by the Joseph J. Jacobs Institute of Molecular Engineering for Medicine and the NSF Center for the Science and Engineering of Materials at Caltech, and by an NIH training grant (to C. L. T.).
Funders:
Funding AgencyGrant Number
Joseph J. Jacobs Institute of Molecular Engineering for MedicineUNSPECIFIED
NSFUNSPECIFIED
NIHUNSPECIFIED
Issue or Number:16
Classification Code:PACS: 87.16.dj, 82.60.Nh, 87.16.dt
DOI:10.1103/PhysRevLett.106.168101
Record Number:CaltechAUTHORS:20110525-082556253
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110525-082556253
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:23787
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Jun 2011 21:28
Last Modified:09 Nov 2021 16:17

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