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Dynamic Construction of Stimulus Values in the Ventromedial Prefrontal Cortex

Harris, Alison and Adolphs, Ralph and Camerer, Colin and Rangel, Antonio (2011) Dynamic Construction of Stimulus Values in the Ventromedial Prefrontal Cortex. PLoS ONE, 6 (6). Art. No. e21074. ISSN 1932-6203. PMCID PMC3114863. https://resolver.caltech.edu/CaltechAUTHORS:20110705-100851671

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Abstract

Signals representing the value assigned to stimuli at the time of choice have been repeatedly observed in ventromedial prefrontal cortex (vmPFC). Yet it remains unknown how these value representations are computed from sensory and memory representations in more posterior brain regions. We used electroencephalography (EEG) while subjects evaluated appetitive and aversive food items to study how event-related responses modulated by stimulus value evolve over time. We found that value-related activity shifted from posterior to anterior, and from parietal to central to frontal sensors, across three major time windows after stimulus onset: 150–250 ms, 400–550 ms, and 700–800 ms. Exploratory localization of the EEG signal revealed a shifting network of activity moving from sensory and memory structures to areas associated with value coding, with stimulus value activity localized to vmPFC only from 400 ms onwards. Consistent with these results, functional connectivity analyses also showed a causal flow of information from temporal cortex to vmPFC. Thus, although value signals are present as early as 150 ms after stimulus onset, the value signals in vmPFC appear relatively late in the choice process, and seem to reflect the integration of incoming information from sensory and memory related regions.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1371/journal.pone.0021074DOIArticle
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0021074PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114863/PubMed CentralArticle
ORCID:
AuthorORCID
Adolphs, Ralph0000-0002-8053-9692
Camerer, Colin0000-0003-4049-1871
Additional Information:© 2011 Harris et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received March 3, 2011; Accepted May 18, 2011; Published June 14, 2011. Editor: Ben J. Harrison, The University of Melbourne, Australia. Funding: Financial support from the Gordon and Betty Moore Foundation (AR, CC, RA) and NSF (AR, RA) is gratefully acknowledged. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Author Contributions: Conceived and designed the experiments: AH RA CC AR. Performed the experiments: AH. Analyzed the data: AH. Wrote the paper: AH RA CC AR.
Funders:
Funding AgencyGrant Number
Gordon and Betty Moore Foundation UNSPECIFIED
NSFUNSPECIFIED
Issue or Number:6
PubMed Central ID:PMC3114863
Record Number:CaltechAUTHORS:20110705-100851671
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110705-100851671
Official Citation:Harris A, Adolphs R, Camerer C, Rangel A (2011) Dynamic Construction of Stimulus Values in the Ventromedial Prefrontal Cortex. PLoS ONE 6(6): e21074. doi:10.1371/journal.pone.0021074
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24290
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Jul 2011 23:07
Last Modified:03 Oct 2019 02:55

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